ENSMUSG00000037379


Mus musculus

Features
Gene ID: ENSMUSG00000037379
  
Biological name :Spon2
  
Synonyms : Q8BMS2 / Spon2 / Spondin-2
  
Possible biological names infered from orthology : Q9BUD6
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 33198184
Gene end: 33218455
  
Corresponding Affymetrix probe sets: 10529264 (MoGene1.0st)   1417860_a_at (Mouse Genome 430 2.0 Array)   1458175_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144416
Ensembl peptide - ENSMUSP00000042701
NCBI entrez gene - 100689     See in Manteia.
MGI - MGI:1923724
RefSeq - NM_133903
RefSeq - XM_006503622
RefSeq Peptide - NP_598664
swissprot - A0A0J9YUZ7
swissprot - Q8BMS2
Ensembl - ENSMUSG00000037379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spon2bENSDARG00000002732Danio rerio
 SPON2ENSGALG00000038433Gallus gallus
 SPON2ENSG00000159674Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spon1 / Q8VCC9 / spondin 1, (f-spondin) extracellular matrix protein / Q9HCB6* / spondin 1*ENSMUSG0000003815633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR009465  Spondin, N-terminal
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002448 mast cell mediated immunity IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008228 opsonization IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043152 induction of bacterial agglutination IDA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060907 positive regulation of macrophage cytokine production IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0003823 antigen binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr