ENSMUSG00000039298


Mus musculus

Features
Gene ID: ENSMUSG00000039298
  
Biological name :Cdk5rap2
  
Synonyms : Cdk5rap2 / CDK5 regulatory subunit-associated protein 2 / Q8K389
  
Possible biological names infered from orthology : Q96SN8
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C2
Gene start: 70216856
Gene end: 70410443
  
Corresponding Affymetrix probe sets: 10513824 (MoGene1.0st)   1443976_at (Mouse Genome 430 2.0 Array)   1447103_at (Mouse Genome 430 2.0 Array)   1452618_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075856
Ensembl peptide - ENSMUSP00000116928
Ensembl peptide - ENSMUSP00000119151
Ensembl peptide - ENSMUSP00000119891
NCBI entrez gene - 214444     See in Manteia.
MGI - MGI:2384875
RefSeq - NM_001313762
RefSeq - NM_145990
RefSeq Peptide - NP_001300691
RefSeq Peptide - NP_666102
swissprot - Q8K389
swissprot - F6R2K5
swissprot - Q5SP75
swissprot - H7BX43
Ensembl - ENSMUSG00000039298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:55582ENSDARG00000024219Danio rerio
 CDK5RAP2ENSGALG00000041102Gallus gallus
 Q96SN8ENSG00000136861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80YT7 / Pde4dip / phosphodiesterase 4D interacting protein (myomegalin) / Q5VU43* / phosphodiesterase 4D interacting protein*ENSMUSG0000003817024


Protein motifs (from Interpro)
Interpro ID Name
 IPR012943  Centrosomin, N-terminal motif 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0031023 microtubule organizing center organization IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046600 negative regulation of centriole replication IMP
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0008274 gamma-tubulin ring complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0015631 tubulin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Cdk5rap2Gt(RRO242)Byg/Cdk5rap2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdk5rap2Gt(RRO242)Byg/Cdk5rap2an
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: involves: C57BL/6 * WB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Cdk5rap2Gt(RRO242)Byg/Cdk5rap2an
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2Gt(RRO242)Byg/Cdk5rap2an
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

Allelic Composition: Cdk5rap2Gt(RRU031)Byg/Cdk5rap2Gt(RRU031)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lpcat1rd11-2J/Lpcat1rd11-2J
Genetic Background: B6.Cg-Lpcat1rd11-2J/Boc

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

Allelic Composition: Cdk5rap2Gt(RRF465)Byg/Cdk5rap2Gt(RRF465)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5rap2Gt(RRF465)Byg/Cdk5rap2Gt(RRF465)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Cdk5rap2an/Cdk5rap2an,Tyrp1B-lt/Tyrp1B-lt
Genetic Background: WBB6F1

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

Allelic Composition: Cdk5rap2Gt(RRF465)Byg/Cdk5rap2Gt(RRF465)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk5rap2tm1a(EUCOMM)Wtsi/Cdk5rap2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cdk5rap2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Cdk5rap2an/Cdk5rap2an
Genetic Background: B6.Cg-Cdk5rap2an

 MP:0013539 increased ovary adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the ovary, occurring in a specific population in a given time period" [MGI:Anna]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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