ENSMUSG00000039354


Mus musculus

Features
Gene ID: ENSMUSG00000039354
  
Biological name :Smarcal1
  
Synonyms : Q8BJL0 / Smarcal1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
  
Possible biological names infered from orthology : Q9NZC9 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 72583251
Gene end: 72633134
  
Corresponding Affymetrix probe sets: 10347254 (MoGene1.0st)   1416620_at (Mouse Genome 430 2.0 Array)   1439142_at (Mouse Genome 430 2.0 Array)   1455139_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137833
Ensembl peptide - ENSMUSP00000047589
Ensembl peptide - ENSMUSP00000114848
Ensembl peptide - ENSMUSP00000120230
NCBI entrez gene - 54380     See in Manteia.
MGI - MGI:1859183
RefSeq - XM_011238557
RefSeq - XM_006496142
RefSeq - XM_006496143
RefSeq - XM_006496144
RefSeq - XM_006496145
RefSeq - NM_018817
RefSeq - XM_006496141
RefSeq Peptide - NP_061287
swissprot - D3Z0J8
swissprot - D3YUX5
swissprot - Q8BJL0
Ensembl - ENSMUSG00000039354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smarcal1ENSDARG00000102265Danio rerio
 SMARCAL1ENSGALG00000011475Gallus gallus
 Q9NZC9ENSG00000138375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6NZP1 / Zranb3 / zinc finger, RAN-binding domain containing 3 / Q5FWF4* / zinc finger RANBP2-type containing 3*ENSMUSG0000003608624
Btaf1 / B-TFIID TATA-box binding protein associated factor 1 / O14981*ENSMUSG0000004056523


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR010003  HARP domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030101  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0006259 DNA metabolic process ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0031297 replication fork processing ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005662 DNA replication factor A complex ISO
 cellular_componentGO:0035861 site of double-strand break ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036310 annealing helicase activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slx4tm1a(EUCOMM)Wtsi/Slx4tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Slx4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Gli3tm1.1Zllr/Gli3tm1.2Zllr,Hoxa13tm1.1(cre)Makm/Hoxa13+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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