ENSMUSG00000039410


Mus musculus

Features
Gene ID: ENSMUSG00000039410
  
Biological name :Prdm16
  
Synonyms : A2A935 / Prdm16 / PR domain zinc finger protein 16
  
Possible biological names infered from orthology : PR/SET domain 16 / Q9HAZ2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 154316125
Gene end: 154636873
  
Corresponding Affymetrix probe sets: 10519028 (MoGene1.0st)   1429308_at (Mouse Genome 430 2.0 Array)   1429309_at (Mouse Genome 430 2.0 Array)   1440745_at (Mouse Genome 430 2.0 Array)   1440870_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064546
Ensembl peptide - ENSMUSP00000030902
Ensembl peptide - ENSMUSP00000095365
Ensembl peptide - ENSMUSP00000117598
Ensembl peptide - ENSMUSP00000101263
Ensembl peptide - ENSMUSP00000101262
Ensembl peptide - ENSMUSP00000101261
NCBI entrez gene - 70673     See in Manteia.
MGI - MGI:1917923
RefSeq - XM_006539179
RefSeq - NM_001177995
RefSeq - NM_001291026
RefSeq - NM_001291029
RefSeq - NM_027504
RefSeq - XM_006539171
RefSeq - XM_006539172
RefSeq - XM_006539173
RefSeq - XM_006539174
RefSeq - XM_006539175
RefSeq - XM_006539178
RefSeq Peptide - NP_001171466
RefSeq Peptide - NP_001277955
RefSeq Peptide - NP_001277958
RefSeq Peptide - NP_081780
swissprot - A2A930
swissprot - A2A935
swissprot - A2A929
swissprot - A2A934
swissprot - A2A933
swissprot - A2A931
Ensembl - ENSMUSG00000039410
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRDM16ENSDARG00000078324Danio rerio
 PRDM16ENSGALG00000036728Gallus gallus
 PRDM16ENSG00000142611Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mecom / P14404 / MDS1 and EVI1 complex locus / Q03112*ENSMUSG0000002768430
E9PZZ1 / Prdm13 / PR domain zinc finger protein 13 / Q9H4Q3* / PR/SET domain 13*ENSMUSG000000404789


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR030414  PR domain zinc finger protein 16
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0022008 neurogenesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0030853 negative regulation of granulocyte differentiation ISO
 biological_processGO:0035019 somatic stem cell population maintenance IDA
 biological_processGO:0043457 regulation of cellular respiration IDA
 biological_processGO:0043586 tongue development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0050872 white fat cell differentiation IDA
 biological_processGO:0050873 brown fat cell differentiation IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016235 aggresome ISO
 cellular_componentGO:0017053 transcriptional repressor complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000448 pointed snout "nose tapers to a small tip, sharper angle than wild type " [J:18378]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig4tm2.1Fwa/Lig4tm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004035 abnormal sublingual gland morphology "malformation of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009522 submandibular gland hypoplasia "underdevelopment or reduced size of either of the large major salivary glands situated beneath the mandible, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0009525 abnormal submandibular duct morphology "any strucutral anomaly of the duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0009527 abnormal sublingual duct morphology "any structural anomaly of the canals that drain the sublingual gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Atrnmg/Atrnmg
Genetic Background: LDJ/Le

Allelic Composition: Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

Allelic Composition: Prdm16csp1/Prdm16+
Genetic Background: FVB.C-Prdm16csp1

Allelic Composition: Prdm16csp1/Prdm16Gt(OST67423)Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/c * C57BL/6J * FVB/NJ

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011615 submucous cleft palate "a cleft of the soft palate with cardinal signs including a bifid uvula, a V-shaped notch at the back of the hard palate, a translucent line in the midline of the soft palate and a short palate" [PMID:19779505]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: involves: BALB/c * C57BL/6J * FVB/NJ

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020520 whitened brown adipose tissue morphology "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
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Allelic Composition: Prdm16tm1.1Brsp/Prdm16tm1.1Brsp,Myf5tm1(cre)Mrc/Myf5+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP/Vamp2)Ggc/Gt(ROSA)26Sor+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0030191 narrow snout "decreased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

 MP:0030248 narrow maxilla "reduced width of the upper bony framework of the mouth where the superior teeth are held" [MGI:anna]
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Allelic Composition: Prdm16csp1/Prdm16csp1
Genetic Background: FVB.C-Prdm16csp1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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