ENSMUSG00000027684


Mus musculus

Features
Gene ID: ENSMUSG00000027684
  
Biological name :Mecom
  
Synonyms : MDS1 and EVI1 complex locus / Mecom / P14404
  
Possible biological names infered from orthology : Q03112
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A3
Gene start: 29951296
Gene end: 30548008
  
Corresponding Affymetrix probe sets: 10497590 (MoGene1.0st)   10497608 (MoGene1.0st)   1422295_at (Mouse Genome 430 2.0 Array)   1423011_at (Mouse Genome 430 2.0 Array)   1438325_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134626
Ensembl peptide - ENSMUSP00000051057
Ensembl peptide - ENSMUSP00000103905
Ensembl peptide - ENSMUSP00000103906
Ensembl peptide - ENSMUSP00000128563
Ensembl peptide - ENSMUSP00000133310
Ensembl peptide - ENSMUSP00000133410
Ensembl peptide - ENSMUSP00000133942
Ensembl peptide - ENSMUSP00000134117
Ensembl peptide - ENSMUSP00000134152
Ensembl peptide - ENSMUSP00000134278
Ensembl peptide - ENSMUSP00000134303
NCBI entrez gene - 14013     See in Manteia.
MGI - MGI:95457
RefSeq - XM_011249664
RefSeq - NM_007963
RefSeq - XM_006535387
RefSeq - XM_006535393
RefSeq - XM_006535394
RefSeq - XM_011249656
RefSeq - XM_011249657
RefSeq - XM_011249658
RefSeq - XM_011249659
RefSeq - XM_011249660
RefSeq - XM_011249661
RefSeq - XM_011249662
RefSeq - XM_011249663
RefSeq Peptide - NP_031989
swissprot - Q8CCA6
swissprot - G3UWT0
swissprot - G3UY46
swissprot - G3UYK2
swissprot - G3UYN3
swissprot - G3UYY9
swissprot - G3UZ13
swissprot - G3UZT5
swissprot - H9T841
swissprot - G3UWJ0
swissprot - F6SZX1
swissprot - P14404
swissprot - O35700
Ensembl - ENSMUSG00000027684
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mecomENSDARG00000060808Danio rerio
 MECOMENSGALG00000032577Gallus gallus
 MECOMENSG00000085276Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2A935 / Prdm16 / PR domain zinc finger protein 16 / Q9HAZ2* / PR/SET domain 16*ENSMUSG0000003941054
E9PZZ1 / Prdm13 / PR domain zinc finger protein 13 / Q9H4Q3* / PR/SET domain 13*ENSMUSG0000004047812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily
 IPR036970  Mds1 and Evi1 complex locus protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001780 neutrophil homeostasis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0035115 embryonic forelimb morphogenesis IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043069 negative regulation of programmed cell death ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046329 negative regulation of JNK cascade ISO
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0060039 pericardium development IMP
 biological_processGO:0071425 hematopoietic stem cell proliferation IMP
 biological_processGO:0072001 renal system development IGI
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IMP
 biological_processGO:0098727 maintenance of cell number IGI
 cellular_componentGO:0000118 histone deacetylase complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001097 abnormal superior glossopharyngeal ganglion morphology "malformation of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001101 abnormal superior vagus ganglion morphology "malformation of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001485 abnormal pinna reflex "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900]
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Allelic Composition: Emx2Pdo/Emx2+
Genetic Background: involves: BALB/c

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

Allelic Composition: MecomJbo/Mecom+
Genetic Background: involves: BALB/c

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm5Tyj/Kras+,Trp53tm1.1Dgk/Trp53tm1.1Dgk
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ngfrtm1.2Vk/Ngfrtm1.2Vk
Genetic Background: involves: 129S2/SvPas * FVB/N

Allelic Composition: Mecomtm1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Mecomtm2.1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Mecomtm1Miku/Mecom+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

 MP:0003873 branchial arch hypoplasia "reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, due to reduced cell number" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: B6.Cg-Mecomtm1.1Miku

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

Allelic Composition: Mecomtm1Miku/Mecom+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0005029 abnormal amnion "malformed innermost layer of the extraembryonic membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006018 abnormal tympanic membrane morphology "any structural alterations in the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane consitutes the boundary between the external and middle ear." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:46639:]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0006295 absent sclerotome "absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae" [J:60303, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: involves: BALB/c

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mecomtm1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Mecomtm2.1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Mecomtm2.1Aspe/Mecomtm2.1Aspe,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * CBA

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sortm1(cre/ERT2)Tyj,Nus1tm1.1Qrm/Nus1tm1.1Qrm
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mecomtm1Miku/Mecomtm1Miku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * CBA

 MP:0011246 abnormal fetal liver hematopoietic progenitor cell morphology "any structural anomaly of a hematopoietic stem cell that resides in the fetal liver; in mice, this cell type is first observed at E10.5" [CL:0002353]
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Allelic Composition: Mecomtm1.1Miku/Mecomtm1.1Miku
Genetic Background: B6.Cg-Mecomtm1.1Miku

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Mecomtm1Aspe/Mecomtm1Aspe
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012184 absent paraxial mesoderm "absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites." [MGI:anna]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012249 absent myotome "absence of the mesoderm that is derived from the somite that is fated to become the musculature" [MGI:anna]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013166 small forelimb buds "reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013168 absent hindlimb buds "absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013708 abnormal hematopoietic precursor cell number "anomaly in the number of a hematopoietic cell that is a precursor of some other hematopoietic cell type" [CL:0008001]
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Allelic Composition: Mecomtm2.2Aspe/Mecomtm2.2Aspe
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0030226 middle ear polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the middle ear" [MGI:anna]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: involves: BALB/c

 MP:0030410 middle ear effusion "fluid accumulation in the middle ear cavity due to dysfunction of the Eustachian tube" [https://www.medscape.org/viewarticle/730698, PMID:1267372]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: involves: BALB/c

 MP:0030414 tympanic membrane perforation "presence of a hole or tear in the tympanic membrane (eardrum)" [https://www.emedicinehealth.com/perforated_eardrum/article_em.htm]
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Allelic Composition: MecomJbo/Mecom+
Genetic Background: C3N.C-MecomJbo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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