ENSDARG00000060808


Danio rerio

Features
Gene ID: ENSDARG00000060808
  
Biological name :mecom
  
Synonyms : MDS1 and EVI1 complex locus / mecom
  
Possible biological names infered from orthology : P14404 / Q03112
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 35372907
Gene end: 35410860
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080486
Ensembl peptide - ENSDARP00000150541
swissprot - F1Q834
ZFIN ID - ZDB-GENE-050208-123
Ensembl - ENSDARG00000060808
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MECOMENSGALG00000032577Gallus gallus
 MECOMENSG00000085276Homo sapiens
 MecomENSMUSG00000027684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRDM16 / si:ch211-263k4.2 / A2A935* / Q9HAZ2* / PR/SET domain 16* / PR domain zinc finger protein 16 *ENSDARG0000007832445
prdm13 / PR domain containing 13 / E9PZZ1* / Q9H4Q3* / PR/SET domain 13* / PR domain zinc finger protein 13 *ENSDARG0000007870110


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030413  Transcription factor hamlet


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0035776 pronephric proximal tubule development IMP
 biological_processGO:0035777 pronephric distal tubule development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048702 embryonic neurocranium morphogenesis IGI
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0072196 proximal/distal pattern formation involved in pronephric nephron development IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1903251 multi-ciliated epithelial cell differentiation IMP
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation heart , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros multi-ciliated epithelial cell increased amount , abnormal
pronephros multi-ciliated epithelial cell aggregated , abnormal
Show

 ZFA:0001078 thymus thymus T cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage shortened , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula shortened , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage increased angle to ceratohyal cartilage , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased size , abnormal
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 ZFA:0001517 ceratobranchial 2 cartilage ceratobranchial 2 cartilage absent , abnormal
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 ZFA:0001518 ceratobranchial 3 cartilage ceratobranchial 3 cartilage absent , abnormal
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 ZFA:0001519 ceratobranchial 4 cartilage ceratobranchial 4 cartilage absent , abnormal
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 ZFA:0001521 ceratobranchial 5 cartilage ceratobranchial 5 cartilage absent , abnormal
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 ZFA:0001580 neurocranium neurocranium decreased thickness , abnormal
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 ZFA:0001621 pronephric proximal straight tubule pronephric proximal straight tubule distended , abnormal
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 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule decreased size , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta amount , ameliorated
ventral wall of dorsal aorta monocyte decreased amount , abnormal
ventral wall of dorsal aorta neutrophil decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
ventral wall of dorsal aorta decreased amount , abnormal
ventral wall of dorsal aorta nucleate erythrocyte decreased amount , abnormal
ventral wall of dorsal aorta hematopoietic multipotent progenitor cell amount , ameliorated
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009258 angioblastic mesenchymal cell angioblastic mesenchymal cell increased amount , abnormal
angioblastic mesenchymal cell decreased amount , abnormal
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 ZFA:0009265 monocyte monocyte decreased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell amount , ameliorated
hematopoietic multipotent progenitor cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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