ENSMUSG00000039449


Mus musculus

Features
Gene ID: ENSMUSG00000039449
  
Biological name :Prpf18
  
Synonyms : pre-mRNA processing factor 18 / Prpf18 / Q8BM39
  
Possible biological names infered from orthology : AL157392.5 / Q99633
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A1
Gene start: 4622058
Gene end: 4652113
  
Corresponding Affymetrix probe sets: 10479794 (MoGene1.0st)   1429614_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041428
Ensembl peptide - ENSMUSP00000116495
Ensembl peptide - ENSMUSP00000141457
NCBI entrez gene - 67229     See in Manteia.
MGI - MGI:1914479
RefSeq - XM_006497530
RefSeq - NM_001356451
RefSeq - NM_026045
RefSeq Peptide - NP_001343380
RefSeq Peptide - NP_080321
swissprot - Q8BM39
swissprot - A0A0A6YW97
Ensembl - ENSMUSG00000039449
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf18ENSDARG00000058306Danio rerio
 ENSGALG00000043593Gallus gallus
 AL157392.5ENSG00000282246Homo sapiens
 PRPF18ENSG00000165630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004098  Prp18
 IPR014906  Pre-mRNA processing factor 4 (PRP4)-like
 IPR036285  PRP4-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000350 generation of catalytic spliceosome for second transesterification step IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0071048 nuclear retention of unspliced pre-mRNA at the site of transcription IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005682 U5 snRNP IBA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0046540 U4/U6 x U5 tri-snRNP complex IBA
 cellular_componentGO:0071021 U2-type post-spliceosomal complex IBA
 molecular_functionGO:0000386 second spliceosomal transesterification activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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