ENSMUSG00000039630


Mus musculus

Features
Gene ID: ENSMUSG00000039630
  
Biological name :Hnrnpu
  
Synonyms : Heteroous nuclear ribonucleoprotein U / Hnrnpu / Q8VEK3
  
Possible biological names infered from orthology : heterogeneous nuclear ribonucleoprotein U / Q00839
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H4
Gene start: 178321108
Gene end: 178337797
  
Corresponding Affymetrix probe sets: 10360542 (MoGene1.0st)   10360544 (MoGene1.0st)   1423050_s_at (Mouse Genome 430 2.0 Array)   1423051_at (Mouse Genome 430 2.0 Array)   1434390_at (Mouse Genome 430 2.0 Array)   1434391_at (Mouse Genome 430 2.0 Array)   1450849_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139751
Ensembl peptide - ENSMUSP00000139959
Ensembl peptide - ENSMUSP00000047571
Ensembl peptide - ENSMUSP00000124147
NCBI entrez gene - 51810     See in Manteia.
MGI - MGI:1858195
RefSeq - XM_017321672
RefSeq - XM_017321673
RefSeq - XM_017321674
RefSeq - NM_016805
RefSeq Peptide - NP_058085
swissprot - Q8VEK3
swissprot - A0A087WPF1
swissprot - A0A087WPX7
Ensembl - ENSMUSG00000039630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnrnpuaENSDARG00000015206Danio rerio
 hnrnpubENSDARG00000004735Danio rerio
 HNRNPUENSGALG00000010671Gallus gallus
 HNRNPUENSG00000153187Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VDM6 / Hnrnpul1 / Heteroous nuclear ribonucleoprotein U-like protein 1 / Q9BUJ2* / heterogeneous nuclear ribonucleoprotein U like 1*ENSMUSG0000004072541
Q00PI9 / Hnrnpul2 / Heteroous nuclear ribonucleoprotein U-like protein 2 / Q1KMD3* / HNRNPUL2-BSCL2* / HNRNPUL2-BSCL2 readthrough (NMD candidate)* / heterogeneous nuclear ribonucleoprotein U like 2*ENSMUSG0000007165939


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003034  SAP domain
 IPR003877  SPRY domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR026745  Heterogeneous nuclear ribonucleoprotein U
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035778  Heterogeneous nuclear ribonucleoprotein U, SPRY domain
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051457 maintenance of protein location in nucleus IEA
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0070934 CRD-mediated mRNA stabilization IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 biological_processGO:1902275 regulation of chromatin organization IEA
 biological_processGO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore IEA
 biological_processGO:1902889 protein localization to spindle microtubule IEA
 biological_processGO:1990280 RNA localization to chromatin IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IDA
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISS
 biological_processGO:2000648 positive regulation of stem cell proliferation IMP
 biological_processGO:2000737 negative regulation of stem cell differentiation IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0070937 CRD-mediated mRNA stability complex IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 cellular_componentGO:0098577 inactive sex chromosome IEA
 cellular_componentGO:1990023 mitotic spindle midzone IEA
 cellular_componentGO:1990498 mitotic spindle microtubule IEA
 cellular_componentGO:1990904 ribonucleoprotein complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001097 TFIIH-class transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008143 poly(A) binding IEA
 molecular_functionGO:0017069 snRNA binding IEA
 molecular_functionGO:0017130 poly(C) RNA binding IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0034046 poly(G) binding IEA
 molecular_functionGO:0036002 pre-mRNA binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA
 molecular_functionGO:0099122 RNA polymerase II C-terminal domain binding IDA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-GCaMP5)Ryba/Gt(ROSA)26Sor+,Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: BckdkGt(OST79912)Lex/BckdkGt(OST79912)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Iduatm1Clk/Iduatm1Clk
Genetic Background: NOD.129(B6)-Prkdcscid Iduatm1Clk/J

 MP:0011629 decreased mitochondria number "fewer than normal number of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0020419 decreased cardiac muscle relaxation "inability or reduced ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [PMID:11565821, RGD:cur]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

 MP:0030567 abnormal I band morphology "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
Show

Allelic Composition: Hnrnputm1.1Tman/Hnrnputm1.1Tman,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJaeSor * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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