ENSMUSG00000040037


Mus musculus

Features
Gene ID: ENSMUSG00000040037
  
Biological name :Negr1
  
Synonyms : Negr1 / neuronal growth regulator 1 / Q80Z24
  
Possible biological names infered from orthology : Q7Z3B1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H4
Gene start: 156561794
Gene end: 157316445
  
Corresponding Affymetrix probe sets: 10497051 (MoGene1.0st)   1456392_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101680
Ensembl peptide - ENSMUSP00000135531
Ensembl peptide - ENSMUSP00000041132
Ensembl peptide - ENSMUSP00000073664
NCBI entrez gene - 320840     See in Manteia.
MGI - MGI:2444846
RefSeq - XM_006501576
RefSeq - XM_006501578
RefSeq - XM_006501577
RefSeq - NM_001039094
RefSeq - NM_177274
RefSeq Peptide - NP_001034183
RefSeq Peptide - NP_796248
swissprot - Q80Z24
swissprot - D3Z4T6
swissprot - A0A4W9
swissprot - H3BKU7
Ensembl - ENSMUSG00000040037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 negr1ENSDARG00000021607Danio rerio
 NEGR1ENSGALG00000011350Gallus gallus
 NEGR1ENSG00000172260Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lsamp / Q8BLK3 / Mus musculus limbic system-associated membrane protein (Lsamp), transcript variant 2, mRNA. / Q13449* / limbic system-associated membrane protein*ENSMUSG0000006108050
Opcml / opioid binding protein/cell adhesion molecule-like / Q14982*ENSMUSG0000006225745
Ntm / Q99PJ0 / Mus musculus neurotrimin (Ntm), transcript variant 7, mRNA. / Q9P121* / neurotrimin*ENSMUSG0000005997445
Iglon5 / Q8HW98 / IgLON family member 5 / A6NGN9*ENSMUSG0000001336737


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Negr1m1H/Negr1m1H
Genetic Background: C3.Cg-Negr1m1H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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