ENSMUSG00000040405


Mus musculus

Features
Gene ID: ENSMUSG00000040405
  
Biological name :Havcr1
  
Synonyms : Havcr1
  
Possible biological names infered from orthology : hepatitis A virus cellular receptor 1 / Q96D42
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.1
Gene start: 46735080
Gene end: 46779578
  
Corresponding Affymetrix probe sets: 10375463 (MoGene1.0st)   1434716_at (Mouse Genome 430 2.0 Array)   1450364_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104847
Ensembl peptide - ENSMUSP00000043827
Ensembl peptide - ENSMUSP00000080503
Ensembl peptide - ENSMUSP00000104846
NCBI entrez gene - 171283     See in Manteia.
MGI - MGI:2159680
RefSeq - XM_011248784
RefSeq - NM_001166631
RefSeq - NM_001166632
RefSeq - NM_134248
RefSeq - XM_006532392
RefSeq - XM_006532393
RefSeq - XM_011248783
RefSeq Peptide - NP_599009
RefSeq Peptide - NP_001160103
RefSeq Peptide - NP_001160104
swissprot - E9QPA7
swissprot - Q3V033
swissprot - A0A0A0MQ86
Ensembl - ENSMUSG00000040405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timd4ENSDARG00000077257Danio rerio
 HAVCR1ENSGALG00000017362Gallus gallus
 HAVCR1ENSG00000113249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Timd2 / T cell immunoglobulin and mucin domain containing 2 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004041361
Gm12169 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000007892432
Timd4 / Q6U7R4 / T-cell immunoglobulin and mucin domain-containing protein 4 / Q96H15* / T cell immunoglobulin and mucin domain containing 4*ENSMUSG0000005554626
Havcr2 / Q8VIM0 / Hepatitis A virus cellular receptor 2 homolog / Q8TDQ0* / hepatitis A virus cellular receptor 2*ENSMUSG0000002039924
BC053393 / cDNA sequence BC053393 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004697424


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faslpr/Faslpr,Havcr1tm1Kuch/Havcr1tm1Kuch
Genetic Background: B6.Cg-Havcr1tm1Kuch Faslpr

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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