ENSMUSG00000040413


Mus musculus

Features
Gene ID: ENSMUSG00000040413
  
Biological name :Timd2
  
Synonyms : T cell immunoglobulin and mucin domain containing 2 / Timd2
  
Possible biological names infered from orthology : HAVCR1 / hepatitis A virus cellular receptor 1 / Q96D42
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.1
Gene start: 46668960
Gene end: 46707061
  
Corresponding Affymetrix probe sets: 10385455 (MoGene1.0st)   1418765_at (Mouse Genome 430 2.0 Array)   1418766_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123042
Ensembl peptide - ENSMUSP00000131540
Ensembl peptide - ENSMUSP00000060891
Ensembl peptide - ENSMUSP00000104848
NCBI entrez gene - 171284     See in Manteia.
MGI - MGI:2159681
RefSeq - NM_001161356
RefSeq - NM_134249
RefSeq - NM_001161355
RefSeq Peptide - NP_599010
RefSeq Peptide - NP_001154827
RefSeq Peptide - NP_001154828
swissprot - A8C1R4
swissprot - D3YUN5
Ensembl - ENSMUSG00000040413
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timd4ENSDARG00000077257Danio rerio
 HAVCR1ENSGALG00000017362Gallus gallus
 HAVCR1ENSG00000113249Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Havcr1 / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004040561
Gm12169 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000007892426
Timd4 / Q6U7R4 / T-cell immunoglobulin and mucin domain-containing protein 4 / Q96H15* / T cell immunoglobulin and mucin domain containing 4*ENSMUSG0000005554623
Havcr2 / Q8VIM0 / Hepatitis A virus cellular receptor 2 homolog / Q8TDQ0* / hepatitis A virus cellular receptor 2*ENSMUSG0000002039923
BC053393 / cDNA sequence BC053393 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004697418


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Abca3tm1Dgen/Abca3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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