ENSMUSG00000040423


Mus musculus

Features
Gene ID: ENSMUSG00000040423
  
Biological name :Rc3h1
  
Synonyms : Q4VGL6 / Rc3h1 / Roquin-1
  
Possible biological names infered from orthology : Q5TC82 / ring finger and CCCH-type domains 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.1
Gene start: 160906418
Gene end: 160974978
  
Corresponding Affymetrix probe sets: 10350992 (MoGene1.0st)   10351013 (MoGene1.0st)   1434933_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037178
Ensembl peptide - ENSMUSP00000124871
NCBI entrez gene - 381305     See in Manteia.
MGI - MGI:2685397
RefSeq - NM_001024952
RefSeq - XM_006496908
RefSeq Peptide - NP_001020123
swissprot - H7BX02
swissprot - Q4VGL6
Ensembl - ENSMUSG00000040423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rc3h1aENSDARG00000062550Danio rerio
 rc3h1bENSDARG00000063182Danio rerio
 RC3H1ENSGALG00000004587Gallus gallus
 RC3H1ENSG00000135870Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rc3h2 / P0C090 / Roquin-2 / Q9HBD1* / ring finger and CCCH-type domains 2*ENSMUSG0000007537651


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR032671  Roquin-1
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0001782 B cell homeostasis IGI
 biological_processGO:0002634 regulation of germinal center formation IMP
 biological_processGO:0002635 negative regulation of germinal center formation IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0033962 cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0042098 T cell proliferation IGI
 biological_processGO:0042129 regulation of T cell proliferation IEA
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0043488 regulation of mRNA stability IMP
 biological_processGO:0045623 negative regulation of T-helper cell differentiation IMP
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:0048535 lymph node development IGI
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0050856 regulation of T cell receptor signaling pathway IMP
 biological_processGO:0050863 regulation of T cell activation IEA
 biological_processGO:0061014 positive regulation of mRNA catabolic process IDA
 biological_processGO:0061158 3"-UTR-mediated mRNA destabilization IDA
 biological_processGO:0061470 T follicular helper cell differentiation IGI
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035613 RNA stem-loop binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1Gt(CC0753)Wtsi/Rc3h1Gt(CC0753)Wtsi
Genetic Background: B6.129P2-Rc3h1Gt(CC0753)Wtsi

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1m1Btlr/Rc3h1m1Btlr
Genetic Background: C57BL/6J-Rc3h1m1Btlr

Allelic Composition: Rc3h1m1Btlr/Rc3h1+
Genetic Background: C57BL/6J-Rc3h1m1Btlr

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

Allelic Composition: Rc3h1Gt(CC0753)Wtsi/Rc3h1Gt(CC0753)Wtsi
Genetic Background: B6.129P2-Rc3h1Gt(CC0753)Wtsi

Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Icostm1Flv/Icostm1Flv,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6JSfdAnu

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thbdtm1.1Hlwu/Thbdtm1.1Hlwu,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.129-Thbdtm1.1Hlwu Lyz2tm1(cre)Ifo

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Rc3h1m1Btlr/Rc3h1m1Btlr
Genetic Background: C57BL/6J-Rc3h1m1Btlr

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu-Tg1/Axin1tm1(Axin2)Cos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB/N

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * NZB * SJL

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * NZB * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rc3h1Gt(CC0753)Wtsi/Rc3h1Gt(CC0753)Wtsi
Genetic Background: B6.129P2-Rc3h1Gt(CC0753)Wtsi

Allelic Composition: Rc3h1san/Rc3h1san
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0010189 abnormal T follicular helper cell physiology "any functional anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Rc3h1san/Rc3h1+
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Icostm1Flv/Icostm1Flv,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6JSfdAnu

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita,Itga1tm1Gdnr/Itga1tm1Gdnr
Genetic Background: C.Cg-Ins2Akita Itga1tm1Gdnr

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rc3h1tm1.2Mass/Rc3h1tm1.2Mass
Genetic Background: involves: C57BL/6 * CBA * CD-1 * NZB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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