ENSMUSG00000075376


Mus musculus

Features
Gene ID: ENSMUSG00000075376
  
Biological name :Rc3h2
  
Synonyms : P0C090 / Rc3h2 / Roquin-2
  
Possible biological names infered from orthology : Q9HBD1 / ring finger and CCCH-type domains 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 37370069
Gene end: 37422903
  
Corresponding Affymetrix probe sets: 10482144 (MoGene1.0st)   1420143_at (Mouse Genome 430 2.0 Array)   1420144_x_at (Mouse Genome 430 2.0 Array)   1426924_at (Mouse Genome 430 2.0 Array)   1426925_at (Mouse Genome 430 2.0 Array)   1438268_at (Mouse Genome 430 2.0 Array)   1446444_at (Mouse Genome 430 2.0 Array)   1456105_at (Mouse Genome 430 2.0 Array)   1460086_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108558
Ensembl peptide - ENSMUSP00000145082
Ensembl peptide - ENSMUSP00000097721
Ensembl peptide - ENSMUSP00000108556
NCBI entrez gene - 319817     See in Manteia.
MGI - MGI:2442789
RefSeq - NM_001290642
RefSeq - XM_006498124
RefSeq - NM_001100591
RefSeq Peptide - NP_001094061
RefSeq Peptide - NP_001277571
swissprot - A0A0N4SVF7
swissprot - P0C090
swissprot - A2AVP4
Ensembl - ENSMUSG00000075376
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rc3h2ENSDARG00000063050Danio rerio
 RC3H2ENSGALG00000001253Gallus gallus
 RC3H2ENSG00000056586Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rc3h1 / Q4VGL6 / Roquin-1 / Q5TC82* / ring finger and CCCH-type domains 1*ENSMUSG0000004042349


Protein motifs (from Interpro)
Interpro ID Name
 IPR000571  Zinc finger, CCCH-type
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027370  RING-type zinc-finger, LisH dimerisation motif
 IPR032670  Roquin-2
 IPR036855  Zinc finger, CCCH-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0001782 B cell homeostasis IGI
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0042098 T cell proliferation IGI
 biological_processGO:0043029 T cell homeostasis IGI
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048535 lymph node development IGI
 biological_processGO:0048536 spleen development IGI
 biological_processGO:0060173 limb development IMP
 biological_processGO:0061470 T follicular helper cell differentiation IGI
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
Show

Allelic Composition: Rc3h1san/Rc3h1san,Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0010995 abnormal lung alveolus development "anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

 MP:0011078 increased macrophage cytokine production "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rc3h1tm1.2Cgv/Rc3h1san
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

Allelic Composition: Rc3h2tm1a(KOMP)Wtsi/Rc3h2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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