ENSMUSG00000041189


Mus musculus

Features
Gene ID: ENSMUSG00000041189
  
Biological name :Chrnb1
  
Synonyms : cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / Chrnb1 / P09690
  
Possible biological names infered from orthology : cholinergic receptor nicotinic beta 1 subunit / P11230
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69784036
Gene end: 69795943
  
Corresponding Affymetrix probe sets: 10387625 (MoGene1.0st)   1420682_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047270
NCBI entrez gene - 11443     See in Manteia.
MGI - MGI:87890
RefSeq - XM_006532005
RefSeq - NM_009601
RefSeq - XM_006532003
RefSeq - XM_006532004
RefSeq Peptide - NP_033731
swissprot - P09690
Ensembl - ENSMUSG00000041189
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrnb1ENSDARG00000069660Danio rerio
 chrnb1lENSDARG00000022532Danio rerio
 CHRNB1ENSG00000170175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625341
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625140
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460938
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052531
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627928
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920526
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226923
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859016


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001941 postsynaptic membrane organization IEA
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006936 muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0035095 behavioral response to nicotine IEA
 biological_processGO:0042391 regulation of membrane potential IGI
 biological_processGO:0048747 muscle fiber development IEA
 biological_processGO:0050877 nervous system process IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0015464 acetylcholine receptor activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IGI
 molecular_functionGO:0042166 acetylcholine binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Psaptm1Suz/Psaptm1Suz
Genetic Background: B6.129P2-Psaptm1Suz

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Psaptm1Suz/Psaptm1Suz
Genetic Background: B6.129P2-Psaptm1Suz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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