ENSMUSG00000008590


Mus musculus

Features
Gene ID: ENSMUSG00000008590
  
Biological name :Htr3b
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 3B / Htr3b / Q9JHJ5
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 3B / O95264
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 48935008
Gene end: 48964990
  
Corresponding Affymetrix probe sets: 10593245 (MoGene1.0st)   1421652_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008734
NCBI entrez gene - 57014     See in Manteia.
MGI - MGI:1861899
RefSeq - NM_020274
RefSeq Peptide - NP_064670
swissprot - Q9JHJ5
Ensembl - ENSMUSG00000008590
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr3bENSDARG00000061749Danio rerio
 HTR3BENSG00000149305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226941
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052522
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627921
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625121
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625320
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460920
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920520
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118918


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008132  5-hydroxytryptamine 3 receptor
 IPR008134  5-hydroxytryptamine 3 receptor, B subunit
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904602 serotonin-activated cation-selective channel complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000008590 Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*  / complex
 ENSMUSG00000032269 Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*  / complex






 

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