ENSMUSG00000032269


Mus musculus

Features
Gene ID: ENSMUSG00000032269
  
Biological name :Htr3a
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 3A / Htr3a
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 3A / P46098
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 48899213
Gene end: 48911099
  
Corresponding Affymetrix probe sets: 10593233 (MoGene1.0st)   1418268_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003826
Ensembl peptide - ENSMUSP00000150647
NCBI entrez gene - 15561     See in Manteia.
MGI - MGI:96282
RefSeq - XM_011242398
RefSeq - NM_001099644
RefSeq - NM_013561
RefSeq Peptide - NP_001093114
RefSeq Peptide - NP_038589
swissprot - Q8K1F4
swissprot - E9QLC0
Ensembl - ENSMUSG00000032269
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr3aENSDARG00000089212Danio rerio
 HTR3AENSGALG00000007004Gallus gallus
 HTR3AENSG00000166736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859036
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052526
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627926
Chrna9 / cholinergic receptor, nicotinic, alpha polypeptide 9 / Q9UGM1* / cholinergic receptor nicotinic alpha 9 subunit*ENSMUSG0000002920524
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118924
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625123
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625320
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460920


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008132  5-hydroxytryptamine 3 receptor
 IPR008133  5-hydroxytryptamine 3 receptor, A subunit
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904602 serotonin-activated cation-selective channel complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IEA
 molecular_functionGO:0051378 serotonin binding IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0001761 abnormal urination pattern "increased or decreased frequency of urination" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr3atm1Ckn/Htr3a+
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

Allelic Composition: Htr3atm1Ckn/Htr3a+
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0003280 urinary incontinence "inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0003608 prostate inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0005302 neurogenic bladder "defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Htr3atm1Ckn/Htr3a+
Genetic Background: involves: 129S1/Sv * C57BL/6J * DBA/2

 MP:0011403 pyelonephritis "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011774 abnormal urinary bladder detrusor smooth muscle morphology "any structural anomaly of the bundles of smooth muscle fibers forming the muscular wall of the urinary bladder, which are arranged in a longitudinal and a circular layer and, on contraction, serve to expel urine" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011777 abnormal male prostatic urethra morphology "any structural anomaly of the widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum)" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011784 abnormal urinary bladder neck morphology "any structural anomaly of the constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011799 increased urinary bladder weight "greater than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011801 urethra obstruction "any impediment or blockage of the canal through which urine is discharged from the bladder in most mammals and through which semen is discharged in the male; usually caused by calculus, or plugs composed of proteinaceous material, cellular debris and possibly crystals" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

 MP:0011802 seminal vesiculitis "local accumulation of fluid, plasma proteins, and leukocytes in the seminal vesicle(s), usually caused by an infection" [MGI:anna]
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Allelic Composition: Syn2tm1Pggd/Syn2tm1Pggd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032269 Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*  / complex
 ENSMUSG00000008590 Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*  / complex






 

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