ENSG00000166736


Homo sapiens

Features
Gene ID: ENSG00000166736
  
Biological name :HTR3A
  
Synonyms : 5-hydroxytryptamine receptor 3A / HTR3A / P46098
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.2
Gene start: 113974881
Gene end: 113990313
  
Corresponding Affymetrix probe sets: 216615_s_at (Human Genome U133 Plus 2.0 Array)   217002_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299961
Ensembl peptide - ENSP00000423653
Ensembl peptide - ENSP00000424776
Ensembl peptide - ENSP00000424189
Ensembl peptide - ENSP00000347754
Ensembl peptide - ENSP00000364648
NCBI entrez gene - 3359     See in Manteia.
OMIM - 182139
RefSeq - NM_000869
RefSeq - NM_001161772
RefSeq - NM_213621
RefSeq Peptide - NP_998786
RefSeq Peptide - NP_000860
RefSeq Peptide - NP_001155244
swissprot - P46098
swissprot - A0A0B4J205
Ensembl - ENSG00000166736
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr3aENSDARG00000089212Danio rerio
 HTR3AENSGALG00000007004Gallus gallus
 Htr3aENSMUSG00000032269Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR3B / O95264 / 5-hydroxytryptamine receptor 3BENSG0000014930537
HTR3E / A5X5Y0 / 5-hydroxytryptamine receptor 3EENSG0000018603831
HTR3C / Q8WXA8 / 5-hydroxytryptamine receptor 3CENSG0000017808431
CHRNA7 / P36544 / cholinergic receptor nicotinic alpha 7 subunitENSG0000017534425
HTR3D / Q70Z44 / 5-hydroxytryptamine receptor 3DENSG0000018609024
Q9GZZ6 / CHRNA10 / cholinergic receptor nicotinic alpha 10 subunitENSG0000012974924
CHRND / Q07001 / cholinergic receptor nicotinic delta subunitENSG0000013590222
CHRNA9 / Q9UGM1 / cholinergic receptor nicotinic alpha 9 subunitENSG0000017434322
CHRNB1 / P11230 / cholinergic receptor nicotinic beta 1 subunitENSG0000017017521
CHRNG / P07510 / cholinergic receptor nicotinic gamma subunitENSG0000019681120
CHRNE / Q04844 / cholinergic receptor nicotinic epsilon subunitENSG0000010855619
Q494W8 / CHRFAM7A / CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusionENSG0000016666418


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008132  5-hydroxytryptamine 3 receptor
 IPR008133  5-hydroxytryptamine 3 receptor, A subunit
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032154 cleavage furrow IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904602 serotonin-activated cation-selective channel complex IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IEA
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IDA
 molecular_functionGO:0051378 serotonin binding IDA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149305 HTR3B / O95264 / 5-hydroxytryptamine receptor 3B  / complex
 ENSG00000186090 HTR3D / Q70Z44 / 5-hydroxytryptamine receptor 3D  / complex
 ENSG00000166736 HTR3A / P46098 / 5-hydroxytryptamine receptor 3A  / complex
 ENSG00000186038 HTR3E / A5X5Y0 / 5-hydroxytryptamine receptor 3E  / complex
 ENSG00000178084 HTR3C / Q8WXA8 / 5-hydroxytryptamine receptor 3C  / complex






 

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