ENSG00000149305


Homo sapiens

Features
Gene ID: ENSG00000149305
  
Biological name :HTR3B
  
Synonyms : 5-hydroxytryptamine receptor 3B / HTR3B / O95264
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.2
Gene start: 113904677
Gene end: 113946565
  
Corresponding Affymetrix probe sets: 221084_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000260191
Ensembl peptide - ENSP00000440894
Ensembl peptide - ENSP00000443118
NCBI entrez gene - 9177     See in Manteia.
OMIM - 604654
RefSeq - XM_017018552
RefSeq - NM_006028
RefSeq - XM_011543063
RefSeq Peptide - NP_006019
swissprot - O95264
swissprot - H0YFX8
Ensembl - ENSG00000149305
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr3bENSDARG00000061749Danio rerio
 Htr3bENSMUSG00000008590Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR3A / P46098 / 5-hydroxytryptamine receptor 3AENSG0000016673643
HTR3E / A5X5Y0 / 5-hydroxytryptamine receptor 3EENSG0000018603829
HTR3C / Q8WXA8 / 5-hydroxytryptamine receptor 3CENSG0000017808427
CHRNA7 / P36544 / cholinergic receptor nicotinic alpha 7 subunitENSG0000017534423
Q9GZZ6 / CHRNA10 / cholinergic receptor nicotinic alpha 10 subunitENSG0000012974921
CHRNA9 / Q9UGM1 / cholinergic receptor nicotinic alpha 9 subunitENSG0000017434321
CHRND / Q07001 / cholinergic receptor nicotinic delta subunitENSG0000013590221
CHRNB1 / P11230 / cholinergic receptor nicotinic beta 1 subunitENSG0000017017520
CHRNG / P07510 / cholinergic receptor nicotinic gamma subunitENSG0000019681120
HTR3D / Q70Z44 / 5-hydroxytryptamine receptor 3DENSG0000018609020
CHRNE / Q04844 / cholinergic receptor nicotinic epsilon subunitENSG0000010855619
Q494W8 / CHRFAM7A / CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusionENSG0000016666417


Protein motifs (from Interpro)
Interpro ID Name
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008132  5-hydroxytryptamine 3 receptor
 IPR008133  5-hydroxytryptamine 3 receptor, A subunit
 IPR008134  5-hydroxytryptamine 3 receptor, B subunit
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904602 serotonin-activated cation-selective channel complex IGI
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0015276 ligand-gated ion channel activity IEA
 molecular_functionGO:0022850 serotonin-gated cation-selective channel activity IGI


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166736 HTR3A / P46098 / 5-hydroxytryptamine receptor 3A  / complex
 ENSG00000149305 HTR3B / O95264 / 5-hydroxytryptamine receptor 3B  / complex






 

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