ENSMUSG00000029205


Mus musculus

Features
Gene ID: ENSMUSG00000029205
  
Biological name :Chrna9
  
Synonyms : cholinergic receptor, nicotinic, alpha polypeptide 9 / Chrna9
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 9 subunit / Q9UGM1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65934921
Gene end: 65977326
  
Corresponding Affymetrix probe sets: 10522186 (MoGene1.0st)   1430086_at (Mouse Genome 430 2.0 Array)   1438837_at (Mouse Genome 430 2.0 Array)   1445615_at (Mouse Genome 430 2.0 Array)   1447214_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144364
Ensembl peptide - ENSMUSP00000031108
Ensembl peptide - ENSMUSP00000144147
NCBI entrez gene - 231252     See in Manteia.
MGI - MGI:1202403
RefSeq - XM_006503947
RefSeq - NM_001081104
RefSeq - XM_006503945
RefSeq - XM_006503946
RefSeq Peptide - NP_001074573
swissprot - G3X8Z7
swissprot - D3Z2J9
swissprot - A0A0J9YUW0
Ensembl - ENSMUSG00000029205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chrna9ENSDARG00000054680Danio rerio
 LO018568.1ENSDARG00000099181Danio rerio
 CHRNA9ENSGALG00000014268Gallus gallus
 CHRNA9ENSG00000174343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chrna10 / cholinergic receptor, nicotinic, alpha polypeptide 10 / Q9GZZ6* / cholinergic receptor nicotinic alpha 10 subunit*ENSMUSG0000006627952
Chrna7 / P49582 / cholinergic receptor, nicotinic, alpha polypeptide 7 / P36544* / cholinergic receptor nicotinic alpha 7 subunit*ENSMUSG0000003052535
Chrnd / P02716 / cholinergic receptor, nicotinic, delta polypeptide / Q07001* / cholinergic receptor nicotinic delta subunit*ENSMUSG0000002625129
Chrng / cholinergic receptor, nicotinic, gamma polypeptide / P07510* / cholinergic receptor nicotinic gamma subunit*ENSMUSG0000002625329
Chrne / P20782 / cholinergic receptor, nicotinic, epsilon polypeptide / Q04844* / cholinergic receptor nicotinic epsilon subunit*ENSMUSG0000001460927
Chrnb1 / P09690 / cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) / P11230* / cholinergic receptor nicotinic beta 1 subunit*ENSMUSG0000004118927
Htr3a / 5-hydroxytryptamine (serotonin) receptor 3A / P46098* / 5-hydroxytryptamine receptor 3A*ENSMUSG0000003226925
Htr3b / Q9JHJ5 / 5-hydroxytryptamine (serotonin) receptor 3B / O95264* / 5-hydroxytryptamine receptor 3B*ENSMUSG0000000859019


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity ISO


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd28tm1a(EUCOMM)Hmgu/Cd28tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cd28tm1a(EUCOMM)Hmgu/H

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chrna9tmElgo/Chrna9+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay,Psrs1PL/J/Psrs1PL/J
Genetic Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2tm1Bay

Allelic Composition: Chrna9tmElgo/Chrna9tmElgo
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004633 abnormal cochlear IHC efferent innervation "any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Chrna9tmElgo/Chrna9tmElgo
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Chrna9tmElgo/Chrna9+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004925 decreased susceptibility to noise-induced hearing loss "less than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chrna9tmElgo/Chrna9tmElgo
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Chrna9tmElgo/Chrna9+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Chrna9tmElgo/Chrna9tmElgo
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Chrna9tmElgo/Chrna9+
Genetic Background: involves: 129S4/SvJae * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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