| MP:0002118 | abnormal lipid homeostasis | "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0002376 | abnormal dendritic cell physiology | "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0002435 | abnormal effector T cell morphology/development | "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0005617 | increased susceptibility to type IV hypersensitivity reaction | "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0008126 | increased dendritic cell number | "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0008561 | decreased tumor necrosis factor secretion | "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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| MP:0008706 | decreased interleukin-6 secretion | "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Ticam1Lps2/Ticam1Lps2
Genetic Background: C57BL/6J-Ticam1Lps2/J
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