ENSG00000117215


Homo sapiens

Features
Gene ID: ENSG00000117215
  
Biological name :PLA2G2D
  
Synonyms : phospholipase A2 group IID / PLA2G2D / Q9UNK4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.12
Gene start: 20111939
Gene end: 20119566
  
Corresponding Affymetrix probe sets: 220423_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482871
Ensembl peptide - ENSP00000364246
NCBI entrez gene - 26279     See in Manteia.
OMIM - 605630
RefSeq - NM_001271814
RefSeq - NM_012400
RefSeq Peptide - NP_001258743
RefSeq Peptide - NP_036532
swissprot - Q9UNK4
swissprot - A0A087WZT4
Ensembl - ENSG00000117215
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLA2G5ENSGALG00000018977Gallus gallus
 Q9WVF6ENSMUSG00000041202Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P14555 / PLA2G2A / phospholipase A2 group IIAENSG0000018825747
Q9BZM2 / PLA2G2F / phospholipase A2 group IIFENSG0000015878643
P39877 / PLA2G5 / phospholipase A2 group VENSG0000012747241
O15496 / PLA2G10 / phospholipase A2 group XENSG0000006976438
Q9NZK7 / PLA2G2E / phospholipase A2 group IIEENSG0000018878437
P04054 / PLA2G1B / phospholipase A2 group IBENSG0000017089034
AC100868.1ENSG0000025841730
OC90 / Q02509 / otoconin 90ENSG0000025311730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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