ENSG00000188257


Homo sapiens

Features
Gene ID: ENSG00000188257
  
Biological name :PLA2G2A
  
Synonyms : P14555 / phospholipase A2 group IIA / PLA2G2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 19975431
Gene end: 19980416
  
Corresponding Affymetrix probe sets: 203649_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383364
Ensembl peptide - ENSP00000364252
NCBI entrez gene - 5320     See in Manteia.
OMIM - 172411
RefSeq - NM_001161728
RefSeq - NM_000300
RefSeq - NM_001161727
RefSeq - NM_001161729
RefSeq Peptide - NP_000291
RefSeq Peptide - NP_001155199
RefSeq Peptide - NP_001155200
RefSeq Peptide - NP_001155201
swissprot - P14555
swissprot - A0A024RA96
Ensembl - ENSG00000188257
  
Related genetic diseases (OMIM): 114500 - {Colorectal cancer}, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLA2G5ENSGALG00000018977Gallus gallus
 Pla2g2aENSMUSG00000058908Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZK7 / PLA2G2E / phospholipase A2 group IIEENSG0000018878451
Q9UNK4 / PLA2G2D / phospholipase A2 group IIDENSG0000011721547
P39877 / PLA2G5 / phospholipase A2 group VENSG0000012747243
Q9BZM2 / PLA2G2F / phospholipase A2 group IIFENSG0000015878640
P04054 / PLA2G1B / phospholipase A2 group IBENSG0000017089036
O15496 / PLA2G10 / phospholipase A2 group XENSG0000006976435
AC100868.1ENSG0000025841726
OC90 / Q02509 / otoconin 90ENSG0000025311726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IDA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0034374 low-density lipoprotein particle remodeling TAS
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0046473 phosphatidic acid metabolic process IDA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response TAS
 biological_processGO:0050830 defense response to Gram-positive bacterium TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004623 phospholipase A2 activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity TAS
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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