ENSMUSG00000058908


Mus musculus

Features
Gene ID: ENSMUSG00000058908
  
Biological name :Pla2g2a
  
Synonyms : Mus musculus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant 1, coding, mRNA. / Pla2g2a
  
Possible biological names infered from orthology : P14555 / phospholipase A2 group IIA
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 138831857
Gene end: 138835186
  
Corresponding Affymetrix probe sets: 10509584 (MoGene1.0st)   1450128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138200
Ensembl peptide - ENSMUSP00000138550
NCBI entrez gene - 18780     See in Manteia.
MGI - MGI:104642
RefSeq - NM_001082531
RefSeq Peptide - NP_001076000
swissprot - S4R1F8
Ensembl - ENSMUSG00000058908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLA2G5ENSGALG00000018977Gallus gallus
 P14555ENSG00000188257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QUL3 / Pla2g2e / Group IIE secretory phospholipase A2 / Q9NZK7* / phospholipase A2 group IIE*ENSMUSG0000002875149
Q9WVF6 / Pla2g2d / phospholipase A2, group IID / Q9UNK4*ENSMUSG0000004120246
Pla2g5 / phospholipase A2, group V / P39877*ENSMUSG0000004119341
Q9QXX3 / Pla2g10 / phospholipase A2, group X / O15496*ENSMUSG0000002268338
Q9Z0Y2 / Pla2g1b / Phospholipase A2 / P04054* / phospholipase A2 group IB*ENSMUSG0000002952237
Q9QZT4 / Pla2g2f / Group IIF secretory phospholipase A2 / Q9BZM2* / phospholipase A2 group IIF*ENSMUSG0000002874934
Oc90 / Q9Z0L3 / Mus musculus otoconin 90 (Oc90), transcript variant 2, mRNA. / Q02509* / AC100868.1* / otoconin 90*ENSMUSG0000001500128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0046473 phosphatidic acid metabolic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: T/tAE5
Genetic Background: Not Specified

 MP:0012424 decreased alimentary system tumor incidence "less than the expected number of tumors originating in the alimentary system in a given population in a given time period" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Pla2g2aMom1-r/Pla2g2a+
Genetic Background: either: (AKR/J x C57BL/6J-ApcMin)F1 or (MA/MyJ x C57BL/6J-ApcMin)F1 or (CAST/EiJ x C57BL/6J-ApcMin)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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