ENSG00000127472


Homo sapiens

Features
Gene ID: ENSG00000127472
  
Biological name :PLA2G5
  
Synonyms : P39877 / phospholipase A2 group V / PLA2G5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.13
Gene start: 20028179
Gene end: 20091190
  
Corresponding Affymetrix probe sets: 206178_at (Human Genome U133 Plus 2.0 Array)   215870_s_at (Human Genome U133 Plus 2.0 Array)   215871_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364249
NCBI entrez gene - 5322     See in Manteia.
OMIM - 601192
RefSeq - XM_011541592
RefSeq - NM_000929
RefSeq - XM_011541590
RefSeq - XM_011541591
RefSeq - XM_005245891
RefSeq - XM_005245892
RefSeq - XM_005245893
RefSeq - XM_011541586
RefSeq - XM_011541587
RefSeq - XM_011541588
RefSeq - XM_011541589
RefSeq Peptide - NP_000920
swissprot - P39877
Ensembl - ENSG00000127472
  
Related genetic diseases (OMIM): 228980 - [Fleck retina, familial benign], 228980
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLA2G5ENSGALG00000018977Gallus gallus
 Pla2g5ENSMUSG00000041193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P14555 / PLA2G2A / phospholipase A2 group IIAENSG0000018825745
Q9UNK4 / PLA2G2D / phospholipase A2 group IIDENSG0000011721543
Q9NZK7 / PLA2G2E / phospholipase A2 group IIEENSG0000018878443
Q9BZM2 / PLA2G2F / phospholipase A2 group IIFENSG0000015878638
O15496 / PLA2G10 / phospholipase A2 group XENSG0000006976437
P04054 / PLA2G1B / phospholipase A2 group IBENSG0000017089030
AC100868.1ENSG0000025841728
OC90 / Q02509 / otoconin 90ENSG0000025311728


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0006663 platelet activating factor biosynthetic process IEA
 biological_processGO:0010518 positive regulation of phospholipase activity IDA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004623 phospholipase A2 activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity TAS
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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