ENSG00000170890


Homo sapiens

Features
Gene ID: ENSG00000170890
  
Biological name :PLA2G1B
  
Synonyms : P04054 / phospholipase A2 group IB / PLA2G1B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 120322111
Gene end: 120327789
  
Corresponding Affymetrix probe sets: 206311_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413594
Ensembl peptide - ENSP00000312286
Ensembl peptide - ENSP00000447233
NCBI entrez gene - 5319     See in Manteia.
OMIM - 172410
RefSeq - NM_000928
RefSeq Peptide - NP_000919
swissprot - Q9BS22
swissprot - F8W062
swissprot - P04054
Ensembl - ENSG00000170890
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g1bENSDARG00000009153Danio rerio
 ENSGALG00000007236Gallus gallus
 PLA2G1BENSGALG00000020989Gallus gallus
 Q9Z0Y2ENSMUSG00000029522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P14555 / PLA2G2A / phospholipase A2 group IIAENSG0000018825735
Q9UNK4 / PLA2G2D / phospholipase A2 group IIDENSG0000011721534
Q9NZK7 / PLA2G2E / phospholipase A2 group IIEENSG0000018878433
O15496 / PLA2G10 / phospholipase A2 group XENSG0000006976432
Q9BZM2 / PLA2G2F / phospholipase A2 group IIFENSG0000015878630
P39877 / PLA2G5 / phospholipase A2 group VENSG0000012747228
OC90 / Q02509 / otoconin 90ENSG0000025311727
AC100868.1ENSG0000025841727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISS
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0002446 neutrophil mediated immunity ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IDA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0007015 actin filament organization TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol ISS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process ISS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0030593 neutrophil chemotaxis ISS
 biological_processGO:0032431 activation of phospholipase A2 activity TAS
 biological_processGO:0032637 interleukin-8 production ISS
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046324 regulation of glucose import ISS
 biological_processGO:0046470 phosphatidylcholine metabolic process IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IC
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050714 positive regulation of protein secretion TAS
 biological_processGO:0050778 positive regulation of immune response ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0032052 bile acid binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IDA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr