ENSG00000069764


Homo sapiens

Features
Gene ID: ENSG00000069764
  
Biological name :PLA2G10
  
Synonyms : O15496 / phospholipase A2 group X / PLA2G10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.12
Gene start: 14672545
Gene end: 14694669
  
Corresponding Affymetrix probe sets: 207222_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393847
Ensembl peptide - ENSP00000456433
NCBI entrez gene - 8399     See in Manteia.
OMIM - 603603
RefSeq - XM_011522697
RefSeq - NM_003561
RefSeq Peptide - NP_003552
swissprot - O15496
swissprot - H3BRW4
Ensembl - ENSG00000069764
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:92162ENSDARG00000099344Danio rerio
 ENSGALG00000019233Gallus gallus
 PLA2G10ENSGALG00000021314Gallus gallus
 Q9QXX3ENSMUSG00000022683Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UNK4 / PLA2G2D / phospholipase A2 group IIDENSG0000011721533
Q9NZK7 / PLA2G2E / phospholipase A2 group IIEENSG0000018878432
P14555 / PLA2G2A / phospholipase A2 group IIAENSG0000018825731
P39877 / PLA2G5 / phospholipase A2 group VENSG0000012747231
Q9BZM2 / PLA2G2F / phospholipase A2 group IIFENSG0000015878628
P04054 / PLA2G1B / phospholipase A2 group IBENSG0000017089028
AC100868.1ENSG0000025841727
OC90 / Q02509 / otoconin 90ENSG0000025311727


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IC
 biological_processGO:0010884 positive regulation of lipid storage IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process NAS
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IMP
 biological_processGO:0032308 positive regulation of prostaglandin secretion IMP
 biological_processGO:0036148 phosphatidylglycerol acyl-chain remodeling TAS
 biological_processGO:0036149 phosphatidylinositol acyl-chain remodeling TAS
 biological_processGO:0036150 phosphatidylserine acyl-chain remodeling TAS
 biological_processGO:0036151 phosphatidylcholine acyl-chain remodeling TAS
 biological_processGO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0043030 regulation of macrophage activation IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0051977 lysophospholipid transport IDA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion ISS
 biological_processGO:0090370 negative regulation of cholesterol efflux IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0004620 phospholipase activity ISS
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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