| MP:0000279 | ventricular hypoplasia | "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0003641 | small lung | "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0004255 | abnormal spongiotrophoblast layer morphology | "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0005033 | abnormal trophoblast cells | "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)
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| MP:0008092 | abnormal T-helper 2 cell differentiation | "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)
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| MP:0008660 | increased interleukin-10 secretion | "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Mtdhtm1.2Dsar/Mtdhtm1.2Dsar
Genetic Background: either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Prf1tm1Clrk/Prf1tm1Clrk
Genetic Background: C.129S7(B6)-Prf1tm1Clrk
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