ENSMUSG00000042540


Mus musculus

Features
Gene ID: ENSMUSG00000042540
  
Biological name :Acot5
  
Synonyms : Acot5 / acyl-CoA thioesterase 5 / Q6Q2Z6
  
Possible biological names infered from orthology : ACOT1 / ACOT2 / acyl-CoA thioesterase 1 / acyl-CoA thioesterase 2 / P49753 / Q86TX2
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D1
Gene start: 84069325
Gene end: 84076020
  
Corresponding Affymetrix probe sets: 10397166 (MoGene1.0st)   1425257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042019
Ensembl peptide - ENSMUSP00000072322
NCBI entrez gene - 217698     See in Manteia.
MGI - MGI:2384969
RefSeq - XM_011244075
RefSeq - NM_001347417
RefSeq - NM_145444
RefSeq - XM_006515693
RefSeq - XM_011244074
RefSeq Peptide - NP_001334346
RefSeq Peptide - NP_663419
swissprot - Q91YQ6
swissprot - Q6Q2Z6
Ensembl - ENSMUSG00000042540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot20ENSDARG00000042510Danio rerio
 acot21ENSDARG00000042513Danio rerio
 acot22ENSDARG00000058945Danio rerio
 ENSGALG00000009292Gallus gallus
 ACOT1ENSG00000184227Homo sapiens
 ACOT2ENSG00000119673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acot3 / Q9QYR7 / acyl-CoA thioesterase 3 / ACOT1* / ACOT2* / P49753* / Q86TX2* / acyl-CoA thioesterase 2* / acyl-CoA thioesterase 1*ENSMUSG0000002122881
Acot1 / O55137 / acyl-CoA thioesterase 1 / ACOT2* / P49753* / Q86TX2* / acyl-CoA thioesterase 2*ENSMUSG0000007294977
Acot2 / Q9QYR9 / acyl-CoA thioesterase 2 / ACOT1* / P49753* / Q86TX2* / acyl-CoA thioesterase 1*ENSMUSG0000002122675
Acot6 / Q32Q92 / Acyl-coenzyme A thioesterase 6 / Q3I5F7* / acyl-CoA thioesterase 6*ENSMUSG0000004348770
Acot4 / Q8BWN8 / acyl-CoA thioesterase 4 / Q8N9L9*ENSMUSG0000005239266
Acnat2 / Q8BGG9 / acyl-coenzyme A amino acid N-acyltransferase 2ENSMUSG0000006031742
Baat / Q91X34 / Bile acid-CoA:amino acid N-acyltransferase / Q14032*ENSMUSG0000003965342
A2AKK5 / Acnat1 / acyl-coenzyme A amino acid N-acyltransferase 1ENSMUSG0000007098542
AC133183.1 / ACOT1* / ACOT2* / Q86TX2* / P49753* / acyl-CoA thioesterase 1* / acyl-CoA thioesterase 2*ENSMUSG0000011347525


Protein motifs (from Interpro)
Interpro ID Name
 IPR006862  Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
 IPR014940  BAAT/Acyl-CoA thioester hydrolase C-terminal
 IPR016662  Acyl-CoA thioesterase, long chain
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IDA
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0006637 acyl-CoA metabolic process IEA
 biological_processGO:0032788 saturated monocarboxylic acid metabolic process IDA
 biological_processGO:0032789 unsaturated monocarboxylic acid metabolic process IDA
 cellular_componentGO:0005777 peroxisome TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016790 thiolester hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity IDA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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