ENSMUSG00000042599


Mus musculus

Features
Gene ID: ENSMUSG00000042599
  
Biological name :Kdm7a
  
Synonyms : Kdm7a / Lysine-specific demethylase 7A / Q3UWM4
  
Possible biological names infered from orthology : lysine demethylase 7A / Q6ZMT4
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 39136623
Gene end: 39206789
  
Corresponding Affymetrix probe sets: 10544148 (MoGene1.0st)   10544150 (MoGene1.0st)   1427359_at (Mouse Genome 430 2.0 Array)   1435867_at (Mouse Genome 430 2.0 Array)   1456150_at (Mouse Genome 430 2.0 Array)   1459820_at (Mouse Genome 430 2.0 Array)   1459821_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002305
NCBI entrez gene - 338523     See in Manteia.
MGI - MGI:2443388
RefSeq - NM_001033430
RefSeq Peptide - NP_001028602
swissprot - Q3UWM4
Ensembl - ENSMUSG00000042599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm7abENSDARG00000018559Danio rerio
 KDM7AENSGALG00000035108Gallus gallus
 KDM7AENSG00000006459Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*ENSMUSG0000004122942
Phf2 / Q9WTU0 / Lysine-specific demethylase PHF2 / O75151* / PHD finger protein 2*ENSMUSG0000003802539
4921501E09Rik / RIKEN cDNA 4921501E09 geneENSMUSG0000002335034
Kdm2b / Q6P1G2 / Lysine-specific demethylase 2B / Q8NHM5* / lysine demethylase 2B*ENSMUSG0000002947523
Kdm2a / lysine demethylase 2A / Q9Y2K7*ENSMUSG0000005461121
Fbxl19 / Q6PB97 / F-box/LRR-repeat protein 19 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSMUSG000000308115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030901 midbrain development ISS
 biological_processGO:0033169 histone H3-K9 demethylation IMP
 biological_processGO:0035574 histone H4-K20 demethylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 biological_processGO:0071557 histone H3-K27 demethylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IMP
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0035575 histone demethylase activity (H4-K20 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IEA
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IMP


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004650 increased lumbar vertebrae number "increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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