ENSMUSG00000038025


Mus musculus

Features
Gene ID: ENSMUSG00000038025
  
Biological name :Phf2
  
Synonyms : Lysine-specific demethylase PHF2 / Phf2 / Q9WTU0
  
Possible biological names infered from orthology : O75151 / PHD finger protein 2
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A5
Gene start: 48801750
Gene end: 48871119
  
Corresponding Affymetrix probe sets: 10409076 (MoGene1.0st)   1421067_a_at (Mouse Genome 430 2.0 Array)   1421068_at (Mouse Genome 430 2.0 Array)   1421069_at (Mouse Genome 430 2.0 Array)   1434924_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047308
NCBI entrez gene - 18676     See in Manteia.
MGI - MGI:1338034
RefSeq - NM_011078
RefSeq Peptide - NP_035208
swissprot - Q9WTU0
Ensembl - ENSMUSG00000038025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf2ENSDARG00000018691Danio rerio
 PHF2ENSGALG00000039208Gallus gallus
 PHF2ENSG00000197724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*ENSMUSG0000004122948
Kdm7a / Q3UWM4 / Lysine-specific demethylase 7A / Q6ZMT4* / lysine demethylase 7A*ENSMUSG0000004259934
4921501E09Rik / RIKEN cDNA 4921501E09 geneENSMUSG0000002335033
Kdm2b / Q6P1G2 / Lysine-specific demethylase 2B / Q8NHM5* / lysine demethylase 2B*ENSMUSG0000002947522
Kdm2a / lysine demethylase 2A / Q9Y2K7*ENSMUSG0000005461120
Fbxl19 / Q6PB97 / F-box/LRR-repeat protein 19 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSMUSG000000308117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006482 protein demethylation IEA
 biological_processGO:0033169 histone H3-K9 demethylation IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061188 negative regulation of chromatin silencing at rDNA IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus ISS
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009299 decreased mesenteric fat pad weight 
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Bmi1)Aiwa/Gt(ROSA)26Sor+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019947 Arid5b / Q8BM75 / AT-rich interactive domain-containing protein 5B / Q14865* / AT-rich interaction domain 5B*  / complex






 

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