Manteia - Molecule gene

ENSMUSG00000019947

Mus musculus

Features

Gene ID:	ENSMUSG00000019947

Biological name :	Arid5b

Synonyms :	Arid5b / AT-rich interactive domain-containing protein 5B / Q8BM75

Possible biological names infered from orthology :	AT-rich interaction domain 5B / Q14865

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	B5.2
Gene start:	68092520
Gene end:	68278740

Corresponding Affymetrix probe sets:	10369792 (MoGene1.0st) 1420972_at (Mouse Genome 430 2.0 Array) 1420973_at (Mouse Genome 430 2.0 Array) 1434283_at (Mouse Genome 430 2.0 Array) 1442176_at (Mouse Genome 430 2.0 Array) 1458238_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000020106 Ensembl peptide - ENSMUSP00000151227 Ensembl peptide - ENSMUSP00000151665 NCBI entrez gene - 71371 See in Manteia. MGI - MGI:2175912 RefSeq - XM_006514133 RefSeq - NM_023598 RefSeq - XM_006514130 RefSeq - XM_006514131 RefSeq - XM_006514132 RefSeq - XM_006514129 RefSeq Peptide - NP_076087 swissprot - Q8BM75 swissprot - A0A1X7SB62 Ensembl - ENSMUSG00000019947

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
arid5b	ENSDARG00000037196	Danio rerio
ARID5B	ENSGALG00000031534	Gallus gallus
ARID5B	ENSG00000150347	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Arid5a / Q3U108 / AT-rich interactive domain-containing protein 5A / Q03989* / AT-rich interaction domain 5A*	ENSMUSG00000037447	18
Arid4a / AT rich interactive domain 4A (RBP1-like) / P29374* / AT-rich interaction domain 4A*	ENSMUSG00000048118	13
A2CG63 / Arid4b / AT-rich interactive domain-containing protein 4B / Q4LE39* / AT-rich interaction domain 4B*	ENSMUSG00000039219	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR001606	ARID DNA-binding domain
IPR030408	AT-rich interactive domain-containing protein 5B
IPR036431	ARID DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0001822	kidney development	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IBA
biological_process	GO:0006807	nitrogen compound metabolic process	IMP
biological_process	GO:0008584	male gonad development	IMP
biological_process	GO:0008585	female gonad development	IMP
biological_process	GO:0009791	post-embryonic development	IMP
biological_process	GO:0010761	fibroblast migration	IMP
biological_process	GO:0030325	adrenal gland development	IMP
biological_process	GO:0035264	multicellular organism growth	IMP
biological_process	GO:0045444	fat cell differentiation	IMP
biological_process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP
biological_process	GO:0048468	cell development	IMP
biological_process	GO:0048644	muscle organ morphogenesis	IMP
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO
biological_process	GO:0060021	roof of mouth development	IMP
biological_process	GO:0060325	face morphogenesis	IMP
biological_process	GO:0060612	adipose tissue development	IMP
biological_process	GO:0060613	fat pad development	IMP
biological_process	GO:1990830	cellular response to leukemia inhibitory factor	IEP
cellular_component	GO:0005634	nucleus	IBA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0003713	transcription coactivator activity	ISO
molecular_function	GO:0044212	transcription regulatory region DNA binding	IBA

Pathways (from Reactome)

Pathway description

HDMs demethylate histones

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000003	abnormal adipose tissue morphology	"structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: 129S1/Sv-Arid5b^tm1Whit
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000091	short premaxilla	"reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000097	short maxilla	"reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor} Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: B6.129S1-Arid5b^tm1Whit
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000431	absent palatine shelf	"missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor} Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000711	thymic cortex hypoplasia	"reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000767	abnormal smooth muscle morphology	"anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001119	abnormal female reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001132	absent mature ovarian follicles	"failure of ovarian follicle differentiation" [J:35782]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001255	decreased body height	"decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: 129S1/Sv-Arid5b^tm1Whit
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: B6.129S1-Arid5b^tm1Whit
MP:0001376	abnormal mating receptivity	"deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior" [J:51468]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001377	abnormal copulation	"reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001443	poor grooming	"below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: 129S1/Sv-Arid5b^tm1Whit
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: 129S1/Sv-Arid5b^tm1Whit Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc1^tm3Paw/Shc1^tm4Paw Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc1^tm3Paw/Shc1^tm4Paw Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Shc1^tm3Paw/Shc1^tm4Paw Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002161	abnormal fertility/fecundity	"reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002286	cryptorchism	"failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002637	small uterus	"reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: B6.129S1-Arid5b^tm1Whit
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: B6.129S1-Arid5b^tm1Whit
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0003755	abnormal palate	"anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: B6.129S1-Arid5b^tm1Whit
MP:0008295	abnormal zona reticularis morphology	"any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0009137	decreased brown fat lipid droplet number	"reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0009396	small endometrial glands	"decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0009895	decreased palatine shelf size	"reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor},Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Itk^tm1Litt/Itk^tm1Litt Genetic Background: involves: 129S4/SvJae Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: 129S1/Sv-Arid5b^tm1Whit Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Sall4^tm1Brd/Sall4⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011708	decreased fibroblast cell migration	"reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b^tm1Whit Genetic Background: involves: 129S1/Sv * C57BL/6J Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Arid5b^tm1Whit/Arid5b⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0030189	broad snout	"increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺,Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor},Pdgfra^tm2Sor/Pdgfra⁺ Genetic Background: involves: 129S4/SvJaeSor
MP:0030383	small presphenoid bone	"reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000038025	Phf2 / Q9WTU0 / Lysine-specific demethylase PHF2 / O75151* / PHD finger protein 2*	/ complex

0 s.

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