ENSMUSG00000048118


Mus musculus

Features
Gene ID: ENSMUSG00000048118
  
Biological name :Arid4a
  
Synonyms : Arid4a / AT rich interactive domain 4A (RBP1-like)
  
Possible biological names infered from orthology : AT-rich interaction domain 4A / P29374
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C2
Gene start: 71015990
Gene end: 71098592
  
Corresponding Affymetrix probe sets: 10396205 (MoGene1.0st)   1436191_at (Mouse Genome 430 2.0 Array)   1438464_at (Mouse Genome 430 2.0 Array)   1456420_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121319
Ensembl peptide - ENSMUSP00000035512
Ensembl peptide - ENSMUSP00000121109
NCBI entrez gene - 238247     See in Manteia.
MGI - MGI:2444354
RefSeq - XM_006515834
RefSeq - XM_011244105
RefSeq - XM_017315057
RefSeq - NM_001081195
RefSeq Peptide - NP_001074664
swissprot - Q8BY40
swissprot - E9Q9V1
swissprot - F8VPQ2
Ensembl - ENSMUSG00000048118
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arid4aENSDARG00000043873Danio rerio
 ARID4AENSGALG00000012037Gallus gallus
 ARID4AENSG00000032219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2CG63 / Arid4b / AT-rich interactive domain-containing protein 4B / Q4LE39* / AT-rich interaction domain 4B*ENSMUSG0000003921944
Arid5b / Q8BM75 / AT-rich interactive domain-containing protein 5B / Q14865* / AT-rich interaction domain 5B*ENSMUSG0000001994712
Arid5a / Q3U108 / AT-rich interactive domain-containing protein 5A / Q03989* / AT-rich interaction domain 5A*ENSMUSG000000374477


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001606  ARID DNA-binding domain
 IPR002999  Tudor domain
 IPR012603  RBB1NT
 IPR016197  Chromo-like domain superfamily
 IPR025995  RNA binding activity-knot of a chromodomain
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IGI
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0034773 histone H4-K20 trimethylation IMP
 biological_processGO:0036124 histone H3-K9 trimethylation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0080182 histone H3-K4 trimethylation IMP
 biological_processGO:0097368 establishment of Sertoli cell barrier IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002445 abnormal mononuclear leukocyte morphology/development "anomalous structure, differentiation, or number of either of the mature lymphocytes or monocytes found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003121 genomic imprinting "phenotype resulting from inactivation of specific loci during gametogenesis, but not encoded by the DNA itself" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Snrpntm4Alb/Snrpntm4Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Snrpntm4Alb/Snrpntm4Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005573 increased breathing frequency "greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Snrpntm4Alb/Snrpn+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008878 abnormal DNA methylation during gametogenesis "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
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Allelic Composition: Arid4atm1Alb/Arid4atm1Alb,Arid4btm1Alb/Arid4b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Snrpntm4Alb/Snrpntm4Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
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Allelic Composition: Raf1tm3Ulb/Raf1tm3Ulb
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000080268 Brms1 / Q99N20 / Breast cancer metastasis-suppressor 1 homolog / Q9HCU9* / breast cancer metastasis suppressor 1*  / complex
 ENSMUSG00000020519 Q5SQF8 / Sap30l / Histone deacetylase complex subunit SAP30L / Q9HAJ7* / SAP30 like*  / complex






 

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