ENSMUSG00000080268


Mus musculus

Features
Gene ID: ENSMUSG00000080268
  
Biological name :Brms1
  
Synonyms : Breast cancer metastasis-suppressor 1 homolog / Brms1 / Q99N20
  
Possible biological names infered from orthology : breast cancer metastasis suppressor 1 / Q9HCU9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5041404
Gene end: 5049917
  
Corresponding Affymetrix probe sets: 10460517 (MoGene1.0st)   1417897_at (Mouse Genome 430 2.0 Array)   1426129_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112266
NCBI entrez gene - 107392     See in Manteia.
MGI - MGI:2388804
RefSeq - XM_006531623
RefSeq - NM_134155
RefSeq Peptide - NP_598916
swissprot - Q547N0
swissprot - Q99N20
Ensembl - ENSMUSG00000080268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brms1ENSDARG00000051955Danio rerio
 BRMS1ENSG00000174744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brms1l / Q3U1T3 / Breast cancer metastasis-suppressor 1-like protein / Q5PSV4* / breast cancer metastasis-suppressor 1 like*ENSMUSG0000001207652


Protein motifs (from Interpro)
Interpro ID Name
 IPR013907  Sds3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009987 cellular process IDA
 biological_processGO:0016575 histone deacetylation IBA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0090312 positive regulation of protein deacetylation ISS
 biological_processGO:2000210 positive regulation of anoikis ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0070822 Sin3-type complex IBA
 molecular_functionGO:0004407 histone deacetylase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IBA
 molecular_functionGO:0051059 NF-kappaB binding ISO


Pathways (from Reactome)
Pathway description
HDACs deacetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048118 Arid4a / AT rich interactive domain 4A (RBP1-like) / P29374* / AT-rich interaction domain 4A*  / complex
 ENSMUSG00000020519 Q5SQF8 / Sap30l / Histone deacetylase complex subunit SAP30L / Q9HAJ7* / SAP30 like*  / complex






 

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