ENSMUSG00000054611


Mus musculus

Features
Gene ID: ENSMUSG00000054611
  
Biological name :Kdm2a
  
Synonyms : Kdm2a / lysine demethylase 2A
  
Possible biological names infered from orthology : Q9Y2K7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4314419
Gene end: 4398285
  
Corresponding Affymetrix probe sets: 10464728 (MoGene1.0st)   1435329_at (Mouse Genome 430 2.0 Array)   1438890_at (Mouse Genome 430 2.0 Array)   1443336_at (Mouse Genome 430 2.0 Array)   1444358_at (Mouse Genome 430 2.0 Array)   1454477_at (Mouse Genome 430 2.0 Array)   1455942_at (Mouse Genome 430 2.0 Array)   1458449_at (Mouse Genome 430 2.0 Array)   1460534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135745
Ensembl peptide - ENSMUSP00000140253
Ensembl peptide - ENSMUSP00000139651
Ensembl peptide - ENSMUSP00000047683
Ensembl peptide - ENSMUSP00000076698
Ensembl peptide - ENSMUSP00000135418
Ensembl peptide - ENSMUSP00000135471
Ensembl peptide - ENSMUSP00000135689
NCBI entrez gene - 225876     See in Manteia.
MGI - MGI:1354736
RefSeq - NM_001001984
RefSeq - XM_006531722
RefSeq Peptide - NP_001001984
swissprot - H3BKP6
swissprot - A0A087WQL9
swissprot - H3BLD4
swissprot - H3BL82
swissprot - A0A087WP68
swissprot - F6YRW4
swissprot - H3BKJ9
Ensembl - ENSMUSG00000054611
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm2aaENSDARG00000059653Danio rerio
 kdm2abENSDARG00000078133Danio rerio
 KDM2AENSG00000173120Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdm2b / Q6P1G2 / Lysine-specific demethylase 2B / Q8NHM5* / lysine demethylase 2B*ENSMUSG0000002947554
Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*ENSMUSG0000004122920
Fbxl19 / Q6PB97 / F-box/LRR-repeat protein 19 / Q6PCT2* / F-box and leucine rich repeat protein 19*ENSMUSG0000003081120
Phf2 / Q9WTU0 / Lysine-specific demethylase PHF2 / O75151* / PHD finger protein 2*ENSMUSG0000003802519
4921501E09Rik / RIKEN cDNA 4921501E09 geneENSMUSG0000002335017
Kdm7a / Q3UWM4 / Lysine-specific demethylase 7A / Q6ZMT4* / lysine demethylase 7A*ENSMUSG0000004259917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR001965  Zinc finger, PHD-type
 IPR002857  Zinc finger, CXXC-type
 IPR003347  JmjC domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Evc2tm2.1Mis/Evc2tm2.1Mis,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Kdm2atm1d(KOMP)Mtok/Kdm2atm1d(KOMP)Mtok
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * C57BL/6N

 MP:0011827 impaired neuron differentiation "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith]
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Allelic Composition: Kdm2atm1d(KOMP)Mtok/Kdm2atm1d(KOMP)Mtok
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * C57BL/6N

 MP:0012744 increased neural crest cell apoptosis "increased number of (any population) of neural crest cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Kdm2atm1d(KOMP)Mtok/Kdm2atm1d(KOMP)Mtok
Genetic Background: involves: C57BL/6 * C57BL/6JJcl * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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