ENSG00000173120


Homo sapiens

Features
Gene ID: ENSG00000173120
  
Biological name :KDM2A
  
Synonyms : KDM2A / lysine demethylase 2A / Q9Y2K7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 67119269
Gene end: 67258087
  
Corresponding Affymetrix probe sets: 208987_s_at (Human Genome U133 Plus 2.0 Array)   208988_at (Human Genome U133 Plus 2.0 Array)   208989_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000309302
Ensembl peptide - ENSP00000381640
Ensembl peptide - ENSP00000432786
Ensembl peptide - ENSP00000435776
NCBI entrez gene - 22992     See in Manteia.
OMIM - 605657
RefSeq - XM_017017392
RefSeq - NM_012308
RefSeq - XM_006718480
RefSeq - XM_011544860
RefSeq - XM_011544861
RefSeq - XM_017017391
RefSeq - NM_001256405
RefSeq Peptide - NP_001243334
RefSeq Peptide - NP_036440
swissprot - I3VM54
swissprot - Q9Y2K7
swissprot - I3VM53
Ensembl - ENSG00000173120
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm2aaENSDARG00000059653Danio rerio
 kdm2abENSDARG00000078133Danio rerio
 Kdm2aENSMUSG00000054611Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM2B / Q8NHM5 / lysine demethylase 2BENSG0000008909455
FBXL19 / Q6PCT2 / F-box and leucine rich repeat protein 19ENSG0000009936421
PHF8 / Q9UPP1 / PHD finger protein 8ENSG0000017294320
PHF2 / O75151 / PHD finger protein 2ENSG0000019772419
KDM7A / Q6ZMT4 / lysine demethylase 7AENSG0000000645917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR001965  Zinc finger, PHD-type
 IPR002857  Zinc finger, CXXC-type
 IPR003347  JmjC domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IMP


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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