ENSG00000006459


Homo sapiens

Features
Gene ID: ENSG00000006459
  
Biological name :KDM7A
  
Synonyms : KDM7A / lysine demethylase 7A / Q6ZMT4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q34
Gene start: 140084746
Gene end: 140177035
  
Corresponding Affymetrix probe sets: 221778_at (Human Genome U133 Plus 2.0 Array)   225142_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380692
Ensembl peptide - ENSP00000420143
NCBI entrez gene - 80853     See in Manteia.
RefSeq - XM_011516587
RefSeq - NM_030647
RefSeq Peptide - NP_085150
swissprot - Q6ZMT4
swissprot - H9KVD6
Ensembl - ENSG00000006459
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm7abENSDARG00000018559Danio rerio
 KDM7AENSGALG00000035108Gallus gallus
 Kdm7aENSMUSG00000042599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHF8 / Q9UPP1 / PHD finger protein 8ENSG0000017294342
PHF2 / O75151 / PHD finger protein 2ENSG0000019772439
KDM2B / Q8NHM5 / lysine demethylase 2BENSG0000008909423
KDM2A / Q9Y2K7 / lysine demethylase 2AENSG0000017312021
FBXL19 / Q6PCT2 / F-box and leucine rich repeat protein 19ENSG000000993645


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030901 midbrain development ISS
 biological_processGO:0033169 histone H3-K9 demethylation IEA
 biological_processGO:0035574 histone H4-K20 demethylation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 biological_processGO:0071557 histone H3-K27 demethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0005506 iron ion binding TAS
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IEA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0035575 histone demethylase activity (H4-K20 specific) IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IDA
 molecular_functionGO:0071558 histone demethylase activity (H3-K27 specific) IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
Signaling by BRAF and RAF fusions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006459 KDM7A / Q6ZMT4 / lysine demethylase 7A  / complex






 

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