ENSG00000089094


Homo sapiens

Features
Gene ID: ENSG00000089094
  
Biological name :KDM2B
  
Synonyms : KDM2B / lysine demethylase 2B / Q8NHM5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.31
Gene start: 121429097
Gene end: 121581015
  
Corresponding Affymetrix probe sets: 226215_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474307
Ensembl peptide - ENSP00000445196
Ensembl peptide - ENSP00000480847
Ensembl peptide - ENSP00000366269
Ensembl peptide - ENSP00000366271
Ensembl peptide - ENSP00000398279
Ensembl peptide - ENSP00000437497
Ensembl peptide - ENSP00000437821
Ensembl peptide - ENSP00000438138
Ensembl peptide - ENSP00000440373
Ensembl peptide - ENSP00000440942
Ensembl peptide - ENSP00000442293
Ensembl peptide - ENSP00000443052
Ensembl peptide - ENSP00000444846
Ensembl peptide - ENSP00000445102
NCBI entrez gene - 84678     See in Manteia.
OMIM - 609078
RefSeq - XM_011538875
RefSeq - NM_001005366
RefSeq - NM_032590
RefSeq - XM_005253955
RefSeq - XM_005253956
RefSeq - XM_005253961
RefSeq - XM_011538867
RefSeq - XM_011538868
RefSeq - XM_011538869
RefSeq Peptide - NP_115979
RefSeq Peptide - NP_001005366
swissprot - S4R3G4
swissprot - A0A0C4DGG3
swissprot - Q8NHM5
swissprot - F5GXC2
swissprot - F5GXW2
swissprot - F5H0A1
swissprot - F5H4A7
swissprot - F5H4X4
swissprot - F5H5W7
swissprot - F5H6N6
swissprot - F6SRV7
swissprot - F5H7T7
swissprot - F8WBN2
Ensembl - ENSG00000089094
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm2bbENSDARG00000046010Danio rerio
 KDM2BENSGALG00000004225Gallus gallus
 Kdm2bENSMUSG00000029475Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM2A / Q9Y2K7 / lysine demethylase 2AENSG0000017312048
FBXL19 / Q6PCT2 / F-box and leucine rich repeat protein 19ENSG0000009936424
PHF2 / O75151 / PHD finger protein 2ENSG0000019772418
PHF8 / Q9UPP1 / PHD finger protein 8ENSG0000017294318
KDM7A / Q6ZMT4 / lysine demethylase 7AENSG0000000645916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR001965  Zinc finger, PHD-type
 IPR002857  Zinc finger, CXXC-type
 IPR003347  JmjC domain
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019787  Zinc finger, PHD-finger
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0021555 midbrain-hindbrain boundary morphogenesis ISS
 biological_processGO:0021592 fourth ventricle development ISS
 biological_processGO:0021670 lateral ventricle development ISS
 biological_processGO:0021678 third ventricle development ISS
 biological_processGO:0021993 initiation of neural tube closure ISS
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030900 forebrain development ISS
 biological_processGO:0030901 midbrain development ISS
 biological_processGO:0030902 hindbrain development ISS
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0048596 embryonic camera-type eye morphogenesis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IEA
 biological_processGO:1902459 positive regulation of stem cell population maintenance IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation ISS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0031519 PcG protein complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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