ENSG00000197724


Homo sapiens

Features
Gene ID: ENSG00000197724
  
Biological name :PHF2
  
Synonyms : O75151 / PHD finger protein 2 / PHF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q22.31
Gene start: 93576407
Gene end: 93679587
  
Corresponding Affymetrix probe sets: 207138_at (Human Genome U133 Plus 2.0 Array)   212726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000352185
Ensembl peptide - ENSP00000479936
Ensembl peptide - ENSP00000364525
NCBI entrez gene - 5253     See in Manteia.
OMIM - 604351
RefSeq - XM_005252051
RefSeq - XM_006717143
RefSeq - NM_005392
RefSeq Peptide - NP_005383
swissprot - O75151
swissprot - E7ET14
swissprot - A0A087WW48
Ensembl - ENSG00000197724
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phf2ENSDARG00000018691Danio rerio
 PHF2ENSGALG00000039208Gallus gallus
 Phf2ENSMUSG00000038025Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHF8 / Q9UPP1 / PHD finger protein 8ENSG0000017294348
KDM7A / Q6ZMT4 / lysine demethylase 7AENSG0000000645934
KDM2B / Q8NHM5 / lysine demethylase 2BENSG0000008909421
KDM2A / Q9Y2K7 / lysine demethylase 2AENSG0000017312020
FBXL19 / Q6PCT2 / F-box and leucine rich repeat protein 19ENSG000000993647


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR003347  JmjC domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006482 protein demethylation IDA
 biological_processGO:0033169 histone H3-K9 demethylation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061188 negative regulation of chromatin silencing at rDNA IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IDA
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150347 ARID5B / Q14865 / AT-rich interaction domain 5B  / complex






 

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