ENSMUSG00000043639


Mus musculus

Features
Gene ID: ENSMUSG00000043639
  
Biological name :Rbm20
  
Synonyms : Q3UQS8 / Rbm20 / RNA-binding protein 20
  
Possible biological names infered from orthology : Q5T481 / RNA binding motif protein 20
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53677306
Gene end: 53867080
  
Corresponding Affymetrix probe sets: 10463981 (MoGene1.0st)   1429024_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093665
Ensembl peptide - ENSMUSP00000124363
Ensembl peptide - ENSMUSP00000129447
NCBI entrez gene - 73713     See in Manteia.
MGI - MGI:1920963
RefSeq - XM_011247374
RefSeq - XM_006527385
RefSeq - XM_011247371
RefSeq - XM_011247372
RefSeq - XM_011247373
RefSeq - NM_001170847
RefSeq Peptide - NP_001164318
swissprot - F6TAZ4
swissprot - E9QPB0
swissprot - Q3UQS8
Ensembl - ENSMUSG00000043639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 matr3l1.1ENSDARG00000001162Danio rerio
 RBM20ENSGALG00000008697Gallus gallus
 RBM20ENSG00000203867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Matr3 / Q8K310 / matrin 3 / P43243*ENSMUSG0000003723614
Gm28285ENSMUSG000000997032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR000690  Matrin/U1-C, C2H2-type zinc finger
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR034790  RBM20, RNA recognition motif
 IPR034791  RNA-binding protein 20
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0033120 positive regulation of RNA splicing IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

Allelic Composition: Rbm20tm1Hgra/Rbm20+
Genetic Background: involves: C57BL/6

Allelic Composition: Rbm20tm2.1Hgra/Rbm20+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rbm20tm2.1Hgra/Rbm20+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

Allelic Composition: Rbm20tm1Hgra/Rbm20+
Genetic Background: involves: C57BL/6

Allelic Composition: Rbm20tm2.1Hgra/Rbm20+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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