ENSMUSG00000037236


Mus musculus

Features
Gene ID: ENSMUSG00000037236
  
Biological name :Matr3
  
Synonyms : Matr3 / matrin 3 / Q8K310
  
Possible biological names infered from orthology : P43243
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B2
Gene start: 35562146
Gene end: 35593835
  
Corresponding Affymetrix probe sets: 10454809 (MoGene1.0st)   10454828 (MoGene1.0st)   1434888_a_at (Mouse Genome 430 2.0 Array)   1438368_a_at (Mouse Genome 430 2.0 Array)   1450874_at (Mouse Genome 430 2.0 Array)   1458508_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140128
Ensembl peptide - ENSMUSP00000141189
Ensembl peptide - ENSMUSP00000141135
Ensembl peptide - ENSMUSP00000141027
Ensembl peptide - ENSMUSP00000140853
Ensembl peptide - ENSMUSP00000140846
Ensembl peptide - ENSMUSP00000140401
Ensembl peptide - ENSMUSP00000140286
Ensembl peptide - ENSMUSP00000140148
Ensembl peptide - ENSMUSP00000125761
Ensembl peptide - ENSMUSP00000139437
Ensembl peptide - ENSMUSP00000139525
Ensembl peptide - ENSMUSP00000139745
NCBI entrez gene - 17184     See in Manteia.
MGI - MGI:1298379
RefSeq - NM_010771
RefSeq Peptide - NP_034901
swissprot - A0A087WQZ1
swissprot - A0A087WQP4
swissprot - A0A087WQD6
swissprot - A0A087WNW7
swissprot - A0A087WNP3
swissprot - Q5BL18
swissprot - A0A087WSU2
swissprot - Q8K310
swissprot - A0A087WSP7
swissprot - A0A087WSF8
Ensembl - ENSMUSG00000037236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 matr3l1.1ENSDARG00000000394Danio rerio
 MATR3ENSGALG00000002478Gallus gallus
 MATR3ENSG00000015479Homo sapiens
 MATR3ENSG00000280987Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm20 / Q3UQS8 / RNA-binding protein 20 / Q5T481* / RNA binding motif protein 20*ENSMUSG0000004363920
Gm28285ENSMUSG0000009970312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR000690  Matrin/U1-C, C2H2-type zinc finger
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR034928  Matrin-3, RNA recognition motif 1
 IPR034930  Matrin-3, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002218 activation of innate immune response ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISO
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035198 miRNA binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0003387 coarctation of aorta "narrowing of the aorta" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010429 abnormal heart left ventricle outflow tract morphology "any structural anomaly of the anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010485 aortic arch hypoplasia "underdevelopment or reduced size of the aortic arch, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010527 bicuspid pulmonary valve "the presence of two cusps or leaflets in the pulmonary valve instead of three" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011666 double outlet right ventricle, ventricular defect committed to aorta "a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0012515 abnormal heart apex morphology "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr