ENSMUSG00000044279


Mus musculus

Features
Gene ID: ENSMUSG00000044279
  
Biological name :Crb3
  
Synonyms : Crb3 / Mus musculus crumbs family member 3 (Crb3), transcript variant 2, mRNA. / Q8QZT4
  
Possible biological names infered from orthology : crumbs 3, cell polarity complex component / Q9BUF7
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 57059105
Gene end: 57065918
  
Corresponding Affymetrix probe sets: 10446224 (MoGene1.0st)   1424809_at (Mouse Genome 430 2.0 Array)   1434851_s_at (Mouse Genome 430 2.0 Array)   1455115_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000094902
Ensembl peptide - ENSMUSP00000126402
Ensembl peptide - ENSMUSP00000132502
Ensembl peptide - ENSMUSP00000071729
Ensembl peptide - ENSMUSP00000125760
NCBI entrez gene - 224912     See in Manteia.
MGI - MGI:2670904
RefSeq - XM_006524167
RefSeq - NM_001347408
RefSeq - NM_177638
RefSeq - XM_006524164
RefSeq - XM_006524165
RefSeq Peptide - NP_001334337
RefSeq Peptide - NP_808306
swissprot - Q8QZT4
swissprot - E9PZ04
Ensembl - ENSMUSG00000044279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CRB3ENSG00000130545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity ISA
 biological_processGO:0045216 cell-cell junction organization ISA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Tight junction interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0004967 abnormal kidney epithelium morphology "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008141 decreased small intestinal microvillus size "reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0011350 abnormal proximal convoluted tubule brush border morphology "any structural anomaly of the densely packed microvilli that cover the luminal surface of epithelial cells of the proximal convoluted tubule; microvilli increase the luminal surface area of cells, sense the fluid flow in the tubule lumen and convert this information via biochemical responses into reabsorption" [MGI:anna]
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Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0014080 fused small intestinal villi "partial or complete fusion of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Crb3tm1.2Lprs/Crb3tm1.2Lprs
Genetic Background: B6(Cg)-Crb3tm1.2Lprs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000061859 Patj / Q63ZW7 / Mus musculus PATJ, crumbs cell polarity complex component (Patj), transcript variant 5, mRNA. / Q8NI35* / PATJ, crumbs cell polarity complex component*  / complex / reaction
 ENSMUSG00000021112 Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*  / reaction / complex






 

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