ENSMUSG00000045932


Mus musculus

Features
Gene ID: ENSMUSG00000045932
  
Biological name :Ifit2
  
Synonyms : Ifit2 / Mus musculus interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), transcript variant 2, mRNA.
  
Possible biological names infered from orthology : interferon induced protein with tetratricopeptide repeats 2 / P09913
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 34550694
Gene end: 34576419
  
Corresponding Affymetrix probe sets: 10462613 (MoGene1.0st)   1418293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099890
Ensembl peptide - ENSMUSP00000120411
NCBI entrez gene - 15958     See in Manteia.
MGI - MGI:99449
RefSeq - XM_006526706
RefSeq - NM_001355262
RefSeq - NM_008332
RefSeq - XM_006526705
RefSeq Peptide - NP_032358
RefSeq Peptide - NP_001342191
swissprot - Q6GTM0
swissprot - D3YZ80
Ensembl - ENSMUSG00000045932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR759879.1ENSDARG00000088069Danio rerio
 ifit10ENSDARG00000007467Danio rerio
 ifit11ENSDARG00000090537Danio rerio
 ifit12ENSDARG00000090977Danio rerio
 ifit14ENSDARG00000071012Danio rerio
 ifit15ENSDARG00000043584Danio rerio
 ifit16ENSDARG00000056976Danio rerio
 ifit8ENSDARG00000057173Danio rerio
 IFIT5ENSGALG00000045085Gallus gallus
 IFIT2ENSG00000119922Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifit3 / Q64345 / Interferon-induced protein with tetratricopeptide repeats 3 / O14879*ENSMUSG0000007489639
Ifit3b / IFIT3* / O14879* / interferon induced protein with tetratricopeptide repeats 3*ENSMUSG0000006248839
Ifit1bl1 / interferon induced protein with tetratricpeptide repeats 1B like 1 / IFIT1B* / Q5T764* / interferon induced protein with tetratricopeptide repeats 1B*ENSMUSG0000007933935
Ifit1bl2 / interferon induced protein with tetratricopeptide repeats 1B like 2 / IFIT1B* / Q5T764* / interferon induced protein with tetratricopeptide repeats 1B*ENSMUSG0000006729734
Ifit1 / Q64282 / Interferon-induced protein with tetratricopeptide repeats 1 / Q5T764* / IFIT1B* / interferon induced protein with tetratricopeptide repeats 1B*ENSMUSG0000003445934


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR024124  Interferon-induced protein with tetratricopeptide repeats 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ifit2tm1.1Tac/Ifit2+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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