ENSMUSG00000046352


Mus musculus

Features
Gene ID: ENSMUSG00000046352
  
Biological name :Gjb2
  
Synonyms : gap junction protein, beta 2 / Gjb2 / Q00977
  
Possible biological names infered from orthology : P29033
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 57098600
Gene end: 57104702
  
Corresponding Affymetrix probe sets: 10420362 (MoGene1.0st)   1423271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054343
NCBI entrez gene - 14619     See in Manteia.
MGI - MGI:95720
RefSeq - NM_008125
RefSeq Peptide - NP_032151
swissprot - Q00977
swissprot - Q3UJE9
Ensembl - ENSMUSG00000046352
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cx30.3ENSDARG00000042707Danio rerio
 GJB2ENSGALG00000022720Gallus gallus
 GJB6ENSGALG00000017136Gallus gallus
 GJB2ENSG00000165474Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gjb6 / P70689 / gap junction protein, beta 6 / O95452*ENSMUSG0000004005577
Gjb1 / P28230 / gap junction protein, beta 1 / P08034*ENSMUSG0000004779763
Gjb3 / P28231 / gap junction protein, beta 3 / O75712*ENSMUSG0000004236752
Gjb4 / Q02738 / gap junction protein, beta 4 / Q9NTQ9*ENSMUSG0000004662351
Gjb5 / Q02739 / gap junction protein, beta 5 / O95377*ENSMUSG0000004235747
Gjc3 / Q921C1 / gap junction protein, gamma 3 / Q8NFK1*ENSMUSG0000005696632
Gjd4 / Q8BSD4 / gap junction protein, delta 4 / Q96KN9*ENSMUSG0000003685528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000500  Connexin
 IPR002268  Gap junction beta-2 protein (Cx26)
 IPR013092  Connexin, N-terminal
 IPR017990  Connexin, conserved site
 IPR019570  Gap junction protein, cysteine-rich domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0016264 gap junction assembly IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0044752 response to human chorionic gonadotropin IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1905867 epididymis development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005921 gap junction IEA
 cellular_componentGO:0005922 connexin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 molecular_functionGO:0005243 gap junction channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Transport of connexons to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Trappc10b2b2613Clo/Trappc10b2b2613Clo
Genetic Background: C57BL/6J-Trappc10b2b2613Clo

 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1Ktak/Aim2tm1Ktak
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Mesp2tm13.1(cre/Esr1*)Ysa/Mesp2tm17.1(VP16/Rbpj)Ysa
Genetic Background: involves: C57BL/6 * CBA

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003878 abnormal ear physiology "anomolous function of the ear, not due to an anatomical defect" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
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Allelic Composition: Trappc10b2b2613Clo/Trappc10b2b2613Clo
Genetic Background: C57BL/6J-Trappc10b2b2613Clo

 MP:0003879 abnormal hair cell physiology "anomolous function of the sensory epithelial cells of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
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Allelic Composition: Gt(ROSA)26Sortm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor+
Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Trappc10b2b2613Clo/Trappc10b2b2613Clo
Genetic Background: C57BL/6J-Trappc10b2b2613Clo

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0004265 abnormal placental transport "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Gjb2tm1Ugds/Gjb2tm1Ugds,Tg(Sox10-cre)1Wdr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004482 abnormal interdental cell morphology "any structural anomaly of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004562 abnormal inner hair cell synaptic ribbon morphology "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
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Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0006403 abnormal cochlear endolymph ionic homeostasis "anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010194 absent lymphatic vessels "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gjb2tm3.1(Gjb1)Kwi/Gjb2+,Tg(Tek-cre)1Arnd/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL

Allelic Composition: Gjb2tm3.2(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

Allelic Composition: Gjb2tm3.3(Gjb1)Kwi/Gjb2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: either: (involves: 129S2/SvPas) or (involves: C57BL/6) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Gjb2tm2.2Kwi/Gjb2+,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Gjb2tm1Kkam/Gjb2tm1Kkam,Tg(Mpz-cre)94Imeg/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046352 Gjb2 / Q00977 / gap junction protein, beta 2 / P29033*  / complex






 

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