ENSMUSG00000046982


Mus musculus

Features
Gene ID: ENSMUSG00000046982
  
Biological name :Tshz1
  
Synonyms : Q5DTH5 / Teashirt homolog 1 / Tshz1
  
Possible biological names infered from orthology : Q6ZSZ6 / teashirt zinc finger homeobox 1
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E4
Gene start: 84011627
Gene end: 84086404
  
Corresponding Affymetrix probe sets: 10460057 (MoGene1.0st)   1427232_at (Mouse Genome 430 2.0 Array)   1427233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000089388
NCBI entrez gene - 110796     See in Manteia.
MGI - MGI:1346031
RefSeq - NM_001081300
RefSeq Peptide - NP_001074769
swissprot - Q5DTH5
Ensembl - ENSMUSG00000046982
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tshz1ENSDARG00000005026Danio rerio
 TSHZ1ENSGALG00000013672Gallus gallus
 TSHZ1ENSG00000179981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tshz3 / teashirt zinc finger homeobox 3 / Q63HK5*ENSMUSG0000002121757
Tshz2 / Q68FE9 / teashirt zinc finger family member 2 / Q9NRE2* / teashirt zinc finger homeobox 2*ENSMUSG0000004790749


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR026808  Teashirt homologue 1
 IPR027008  Teashirt family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0060023 soft palate development IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003110 absent malleal processus brevis 
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Core/Tshz1+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Core/Tshz1+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006033 abnormal external auditory canal "malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Core/Tshz1+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0008377 absent manubrium "absence of the handle of the malleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0008382 gonial bone hypoplasia "underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0009879 abnormal arcus anterior morphology "any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0009887 abnormal palatal shelf fusion at midline "any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0009943 abnormal olfactory bulb periglomerular cell morphology "any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [NLX:nlx_cell_091202 "NeuroLex.org"]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009949 abnormal olfactory bulb granule cell layer morphology 
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tshz1tm1Garr/Tshz1tm2.2Garr
Genetic Background: mixed

 MP:0010371 abnormal epiglottis morphology "any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0010728 fusion of atlas and occipital bones "union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0010994 aerophagia "excessive swallowing of air or gas" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tshz1tm1Garr/Tshz1tm2.2Garr
Genetic Background: mixed

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tshz1tm1Core/Tshz1tm1Core
Genetic Background: B6.129P2-Tshz1tm1Core

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tshz1tm1Garr/Tshz1tm1Garr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0030291 short soft palate "reduced length of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult" [MGI:anna]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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