ENSMUSG00000047810


Mus musculus

Features
Gene ID: ENSMUSG00000047810
  
Biological name :Ccdc88b
  
Synonyms : Ccdc88b / Coiled-coil domain-containing protein 88B / Q4QRL3
  
Possible biological names infered from orthology : A6NC98 / coiled-coil domain containing 88B
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 6844623
Gene end: 6858211
  
Corresponding Affymetrix probe sets: 10465446 (MoGene1.0st)   1440245_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109067
NCBI entrez gene - 78317     See in Manteia.
MGI - MGI:1925567
RefSeq - XM_017318313
RefSeq - NM_001081291
RefSeq - XM_006527464
RefSeq - XM_011247402
RefSeq Peptide - NP_001074760
swissprot - Q4QRL3
Ensembl - ENSMUSG00000047810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccdc88bENSDARG00000076189Danio rerio
 A6NC98ENSG00000168071Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5SNZ0 / Ccdc88a / Girdin / Q3V6T2* / coiled-coil domain containing 88A*ENSMUSG0000003274029
Q6VGS5 / Ccdc88c / Protein Daple / Q9P219* / coiled-coil domain containing 88C*ENSMUSG0000002118229
2 / Hook2 / Q7TMK6 / Q96ED9* / hook microtubule tethering protein 2*ENSMUSG0000005256611
3 / Hook3 / Q8BUK6 / Q86VS8* / hook microtubule tethering protein 3*ENSMUSG0000003723411
1 / Hook1 / Q8BIL5 / Q9UJC3* / hook microtubule tethering protein 1*ENSMUSG0000002857210


Protein motifs (from Interpro)
Interpro ID Name
 IPR008636  Hook-like protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IBA
 biological_processGO:0031122 cytoplasmic microtubule organization IBA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0050870 positive regulation of T cell activation IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

Allelic Composition: Ccdc88bm1Pgrs/Ccdc88bm1Pgrs
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/10J

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
Show

Allelic Composition: Srd5a3tm1b(EUCOMM)Wtsi/Srd5a3tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Srd5a3tm1b(EUCOMM)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr