ENSMUSG00000032740


Mus musculus

Features
Gene ID: ENSMUSG00000032740
  
Biological name :Ccdc88a
  
Synonyms : Ccdc88a / Girdin / Q5SNZ0
  
Possible biological names infered from orthology : coiled-coil domain containing 88A / Q3V6T2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.3
Gene start: 29373658
Gene end: 29510808
  
Corresponding Affymetrix probe sets: 10374842 (MoGene1.0st)   1436025_at (Mouse Genome 430 2.0 Array)   1437216_at (Mouse Genome 430 2.0 Array)   1445440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115117
Ensembl peptide - ENSMUSP00000114942
Ensembl peptide - ENSMUSP00000105103
Ensembl peptide - ENSMUSP00000119173
Ensembl peptide - ENSMUSP00000048978
NCBI entrez gene - 108686     See in Manteia.
MGI - MGI:1925177
RefSeq - XM_006514454
RefSeq - XM_017314219
RefSeq - NM_176841
RefSeq - XM_006514455
RefSeq - XM_006514450
RefSeq - XM_006514451
RefSeq - XM_006514452
RefSeq - XM_006514453
RefSeq Peptide - NP_789811
swissprot - Z4YLP6
swissprot - F6R1B7
swissprot - Q5SNZ0
swissprot - Z4YKY0
swissprot - Z4YLN8
Ensembl - ENSMUSG00000032740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccdc88aaENSDARG00000078440Danio rerio
 CCDC88AENSGALG00000043587Gallus gallus
 Q3V6T2ENSG00000115355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6VGS5 / Ccdc88c / Protein Daple / Q9P219* / coiled-coil domain containing 88C*ENSMUSG0000002118247
Q4QRL3 / Ccdc88b / Coiled-coil domain-containing protein 88B / A6NC98* / coiled-coil domain containing 88B*ENSMUSG0000004781023
1 / Hook1 / Q8BIL5 / Q9UJC3* / hook microtubule tethering protein 1*ENSMUSG0000002857210
3 / Hook3 / Q8BUK6 / Q86VS8* / hook microtubule tethering protein 3*ENSMUSG0000003723410
2 / Hook2 / Q7TMK6 / Q96ED9* / hook microtubule tethering protein 2*ENSMUSG000000525669


Protein motifs (from Interpro)
Interpro ID Name
 IPR008636  Hook-like protein family
 IPR027717  Girdin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006275 regulation of DNA replication IMP
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010975 regulation of neuron projection development IDA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0030705 cytoskeleton-dependent intracellular transport IBA
 biological_processGO:0031122 cytoplasmic microtubule organization IBA
 biological_processGO:0031929 TOR signaling IDA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045724 positive regulation of cilium assembly IEA
 biological_processGO:0061024 membrane organization IEA
 biological_processGO:1903566 positive regulation of protein localization to cilium IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043422 protein kinase B binding IPI
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002635 reduced sensorimotor gating 
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88a+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Ccdc88atm3.1Mat/Ccdc88atm3.1Mat
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009949 abnormal olfactory bulb granule cell layer morphology 
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009952 abnormal olfactory bulb subventricular zone morphology "any structural anomaly of the region of mitotically active layer of cells surrounding the lateral brain ventricles that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells, that produce neurons that migrate to the olfactory bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ccdc88atm4.1Mat/Ccdc88atm4.1Mat,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Epb41l3tm1Bhat/Epb41l3tm1.1Bhat,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: FVB/N

Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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