ENSMUSG00000048109


Mus musculus

Features
Gene ID: ENSMUSG00000048109
  
Biological name :Rbm15
  
Synonyms : Rbm15 / RNA binding motif protein 15
  
Possible biological names infered from orthology : Q96T37
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.3
Gene start: 107325421
Gene end: 107333673
  
Corresponding Affymetrix probe sets: 10501091 (MoGene1.0st)   1434514_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054424
NCBI entrez gene - 229700     See in Manteia.
MGI - MGI:2443205
RefSeq - NM_001045807
RefSeq Peptide - NP_001039272
swissprot - Q0VBL3
Ensembl - ENSMUSG00000048109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbm15ENSDARG00000073847Danio rerio
 RBM15ENSGALG00000000401Gallus gallus
 RBM15ENSG00000162775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PHZ5 / Rbm15b / RNA binding motif protein 15B / Q8NDT2*ENSMUSG0000007410241
Spen / spen family transcription repressor / Q96T58* / spen family transcriptional repressor*ENSMUSG0000004076126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR010912  Spen paralogue/orthologue C-terminal, metazoa
 IPR012921  Spen paralogue and orthologue SPOC, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR034470  RBM15, RNA recognition motif 1
 IPR034472  RBM15, RNA recognition motif 2
 IPR034473  RBM15, RNA recognition motif 3
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000398 mRNA splicing, via spliceosome IBA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0007221 positive regulation of transcription of Notch receptor target IDA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060674 placenta blood vessel development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0003676 nucleic acid binding IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr6a1Gt(RRA042)Byg/Nr6a1Gt(RRA042)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Nr6a1Gt(RRA042)Byg/Nr6a1Gt(RRA042)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

Allelic Composition: Rbm15tm1.1(MAL)Dgg/Rbm15tm1.1(MAL)Dgg
Genetic Background: B6.129-Rbm15tm1.1(MAL)Dgg

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1m1/Abl1m1
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbm15tm1.1(MAL)Dgg/Rbm15tm1.1(MAL)Dgg
Genetic Background: B6.129-Rbm15tm1.1(MAL)Dgg

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

Allelic Composition: Rbm15tm1Swm/Rbm15tm1Swm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Jarid2jumonji/Jarid2jumonji
Genetic Background: either: B6.129P2-Jarid2jumonji or D2.129P2-Jarid2jumonji

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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