ENSMUSG00000040761


Mus musculus

Features
Gene ID: ENSMUSG00000040761
  
Biological name :Spen
  
Synonyms : Spen / spen family transcription repressor
  
Possible biological names infered from orthology : Q96T58 / spen family transcriptional repressor
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 141467890
Gene end: 141538597
  
Corresponding Affymetrix probe sets: 10517948 (MoGene1.0st)   1420397_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101412
Ensembl peptide - ENSMUSP00000077925
NCBI entrez gene - 56381     See in Manteia.
MGI - MGI:1891706
RefSeq - XM_006539074
RefSeq - XM_006539069
RefSeq - XM_006539070
RefSeq - XM_006539071
RefSeq - XM_006539073
RefSeq - NM_001347235
RefSeq - NM_019763
RefSeq Peptide - NP_062737
RefSeq Peptide - NP_001334164
swissprot - A2ADB1
swissprot - A2ADB0
Ensembl - ENSMUSG00000040761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch1073-335m2.2ENSDARG00000074332Danio rerio
 spenENSDARG00000074245Danio rerio
 SPENENSGALG00000036932Gallus gallus
 SPENENSG00000065526Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rbm15 / RNA binding motif protein 15 / Q96T37*ENSMUSG000000481097
Q6PHZ5 / Rbm15b / RNA binding motif protein 15B / Q8NDT2*ENSMUSG000000741026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR010912  Spen paralogue/orthologue C-terminal, metazoa
 IPR012921  Spen paralogue and orthologue SPOC, C-terminal
 IPR016194  SPOC-like, C-terminal domain superfamily
 IPR034172  SHARP, RNA recognition motif 1
 IPR034173  SHARP, RNA recognition motif 2
 IPR034174  SHARP, RNA recognition motif 3
 IPR034175  SHARP, RNA recognition motif 4
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008283 small hippocampus "reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tfcp2l1Gt(pLSABetageo)1Sjt/Tfcp2l1Gt(pLSABetageo)1Sjt
Genetic Background: B6.129S1-Tfcp2l1Gt(pLSABetageo)1Sjt

Allelic Composition: Spentm2.2Hon/Spentm2.2Hon
Genetic Background: involves: C57BL/6 * CBA

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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