ENSMUSG00000048490


Mus musculus

Features
Gene ID: ENSMUSG00000048490
  
Biological name :Nrip1
  
Synonyms : Mus musculus nuclear receptor interacting protein 1 (Nrip1), transcript variant 2, mRNA. / Nrip1 / Q8CBD1
  
Possible biological names infered from orthology : nuclear receptor interacting protein 1 / P48552
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.1
Gene start: 76287400
Gene end: 76373827
  
Corresponding Affymetrix probe sets: 10440406 (MoGene1.0st)   1418469_at (Mouse Genome 430 2.0 Array)   1432603_at (Mouse Genome 430 2.0 Array)   1434384_at (Mouse Genome 430 2.0 Array)   1447211_at (Mouse Genome 430 2.0 Array)   1449089_at (Mouse Genome 430 2.0 Array)   1454295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051726
Ensembl peptide - ENSMUSP00000112959
Ensembl peptide - ENSMUSP00000123638
NCBI entrez gene - 268903     See in Manteia.
MGI - MGI:1315213
RefSeq - XM_017317020
RefSeq - NM_001358238
RefSeq - NM_173440
RefSeq - XM_006523050
RefSeq - XM_006523051
RefSeq - XM_006523054
RefSeq Peptide - NP_001345167
RefSeq Peptide - NP_775616
swissprot - A0A1Y7VG73
swissprot - Q8CBD1
Ensembl - ENSMUSG00000048490
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrip1aENSDARG00000068965Danio rerio
 nrip1bENSDARG00000068894Danio rerio
 NRIP1ENSGALG00000015681Gallus gallus
 NRIP1ENSG00000180530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026649  Nuclear receptor-interacting protein 1
 IPR031405  Nuclear receptor-interacting protein 1, repression domain 1
 IPR031406  Nuclear receptor-interacting protein 1, repression domain 2
 IPR031407  Nuclear receptor-interacting protein 1, repression domain 3
 IPR031408  Nuclear receptor-interacting protein 1, repression domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001543 ovarian follicle rupture IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0030728 ovulation IMP
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071392 cellular response to estradiol stimulus ISO
 cellular_componentGO:0000118 histone deacetylase complex IPI
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity ISO
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0035257 nuclear hormone receptor binding ISO
 molecular_functionGO:0035259 glucocorticoid receptor binding ISO
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0042974 retinoic acid receptor binding IPI
 molecular_functionGO:0046965 retinoid X receptor binding IPI


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

Allelic Composition: Nrip1tm1Mpk/Nrip1+
Genetic Background: involves: 129/Ola

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipCat-Tohm/Mip+
Genetic Background: DDI

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction






 

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