ENSMUSG00000049532


Mus musculus

Features
Gene ID: ENSMUSG00000049532
  
Biological name :Sall2
  
Synonyms : Q9QX96 / Sall2 / Sal-like protein 2
  
Possible biological names infered from orthology : Q9Y467 / spalt like transcription factor 2
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 52311172
Gene end: 52328762
  
Corresponding Affymetrix probe sets: 10419704 (MoGene1.0st)   1416638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056401
Ensembl peptide - ENSMUSP00000154331
NCBI entrez gene - 50524     See in Manteia.
MGI - MGI:1354373
RefSeq - NM_001244916
RefSeq - NM_015772
RefSeq Peptide - NP_001231845
RefSeq Peptide - NP_056587
swissprot - Q9QX96
Ensembl - ENSMUSG00000049532
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sall2ENSDARG00000075116Danio rerio
 si:ch211-212k18.5ENSDARG00000103316Danio rerio
 SALL2ENSG00000165821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sall1 / spalt like transcription factor 1 / Q9NSC2*ENSMUSG0000003166531
Sall3 / Q62255 / Sal-like protein 3 / Q9BXA9* / spalt like transcription factor 3*ENSMUSG0000002456530
Sall4 / Q8BX22 / Sal-like protein 4 / Q9UJQ4* / spalt like transcription factor 4*ENSMUSG0000002754724


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016581 NuRD complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Sall1tm1Jkoh/Sall1tm1Jkoh,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Sall1tm1Jkoh/Sall1tm1Jkoh,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic Background: involves: 129S1/Sv * 129X1/Sv * CD-1

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NZW

Allelic Composition: Sall2tm1Jkoh/Sall2+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsixtm2Jtl/Tsix+
Genetic Background: involves: 129 * M. m. castaneus

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tsixtm2Jtl/Tsix+
Genetic Background: involves: 129 * M. m. castaneus

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003604 single kidney 
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sall1tm1Ryn/Sall1tm1Ryn,Sall2tm1Ryn/Sall2tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sall1tm1Jkoh/Sall1tm1Jkoh,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic Background: involves: 129S1/Sv * 129X1/Sv * CD-1

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NZW

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Sall2tm1Jkoh/Sall2+,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Sall2tm1Jkoh/Sall2tm1Jkoh,Sall4Gt(W097E01)Flo/Sall4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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